Make Changes? or just wait it out?

[abcdef]

My husband has had symptoms of low testosterone for a few years. Last year his doctor tested it and it was 508 said it was good and left it at that. His vitamin D was very low and we have correct that. Fast forward a year. He has been so exhausted he can barely make it through his work day.

Tested through LabCorp Total T was 329, Free T was 4.9 and Estradiol was 16.7.

Went to see a urologist who prescribed 50 mg of Clomid (without any other blood work)taken every other day for 3 months and then retest Total T and Estradiol only.

After doing research on this, we realized this wasn't a good choice. He started the process to see Defy but the paperwork/blood work is taking some time to get done. In the meantime he has been taking 12.5 mg of Clomid daily for 3 weeks. The new bloodwork (through Quest)he is doing for Defy came back.

Here's the highlights

Total T 1121 (range 250-827)
Free T (we think they missed it as it's not listed anywhere)
Estradiol 37 (range <=29)
DHEA S 344 (range 70-495)
LH 2.9 (range 1.5-9.3)
TSH 3.23 (range 0.4-4.5)

So we will be sending this into Defy next week (my husband is currently out of town on business)and then I expect it will be at least a few weeks before he gets schedule. We are concerned about leaving him on this dose of Clomid for several more weeks considering how very high it shot up in just 3 weeks. Should he cut back to every other day or every third day? Any opinions on what we be good until he gets scheduled with Defy?

Also a couple of questions for my own understanding

LH seems kinda lowish to me since I thought Clomid was suppose to make this rise (of course maybe it is higher than before but we have no pre-Clomid number for comparison). Would you expect this to be higher based on the dramatic changes to Total T? If so what does that mean?

Also it seems the TSH is higher than desirable (last year it was 2.42). Should he pursue more testing in this area? Could the Clomid have caused the TSH to rise?

Thanks for any insight you can offer.

 

[Gene Devine]

Stay the course until either Dr Saya or Dr Crisler have a chance to do the proper evaluation.

LH is low because his Total Testosterone is on the high end. This happens via the negative feedback loop and what one would expect.

TSH is a bit high and would warrant further testing to rule out hypothyroidism.

You're in good hands with Defy.

 

[Weasel]

Those numbers look awesome to me! Stay the course...

 

[1Draw]

Estradiol is high - 37 (range -less 29) and looks like regular test was done instead of sensitive. Labcorp ranges for estradiol sensitive is 8.0 - 35.0 Maybe a cause of his symptoms. He will have to bear with symptoms until consult with Defy team. It will definitely be worth the wait.

 

[Weasel]

Estradiol is high - 37 (range -less 29) and looks like regular test was done instead of sensitive. Labcorp ranges for estradiol sensitive is 8.0 - 35.0 Maybe a cause of his symptoms. He will have to bear with symptoms until consult with Defy team. It will definitely be worth the wait.

e2 of 37, while above reference range, generally isn't considered high for most men.

 

[ERO]

Definitely not high with a Total T of 1121. If anything its low when considering the ideal T:E ratio.