Lowering trt dose/ increasing frequency of injections question

kelj358 · 2025-11-03T06:50:59-0600

Just out of curiosity, is there a rough estimate on how much your T would change by lowering dosage by roughly 20% and moving to EOD vs 2x a week? I'm not going forward with this until next labs to see exactly where I am, but curious as to the avg difference. Been toying with the idea. Seems like increasing frequency you would need to inject less T? Am I on the right track with that line of thinking or no?

Seagal · 2025-11-03T08:41:04-0600

kelj358 said:
Just out of curiosity, is there a rough estimate on how much your T would change by lowering dosage by roughly 20% and moving to EOD vs 2x a week? I'm not going forward with this until next labs to see exactly where I am, but curious as to the avg difference. Been toying with the idea. Seems like increasing frequency you would need to inject less T? Am I on the right track with that line of thinking or no?

If you keep the weekly T dose constant and increase the injection frequency, it will flatten the curve, i.e. it will reduce the peak and increase the trough T levels.

kelj358 · 2025-11-03T08:48:25-0600

That, I understand. But is it typical practice to slightly lower the dosage when increasing the frequency? Say going from 100 a week to 80 or 90 a week?

Seagal · 2025-11-03T09:35:11-0600

kelj358 said:
That, I understand. But is it typical practice to slightly lower the dosage when increasing the frequency? Say going from 100 a week to 80 or 90 a week?

To me it makes no sense. Maybe some looking only at the trough level and chase a magic number.

radman · 2025-11-03T10:30:34-0600

kelj358 said:
That, I understand. But is it typical practice to slightly lower the dosage when increasing the frequency? Say going from 100 a week to 80 or 90 a week?

I don't think that dose is normally reduced when increasing frequency. If you are doing 100 mg once a week, it would be 50 mg twice a week, for example. The main benefit of doing this is that your peaks and troughs are less pronounced. This appears to be most beneficial with side effects such as polycythemia (increased hematocrit) and estrogenic effects (like breast/nipple tenderness, emotional lability, etc.). In fact, dividing into 3 days per week injections may be optimal, but becomes difficult.