Lower Circulating Androgens Are Associated with Overall Cancer Risk and Prostate Cancer Risk in Men Aged 25–84 Years from the Busselton Health Study

[madman]

In conclusion, in this population of community-dwelling men spanning a wide age range and followed for two decades, lower T and DHT were associated with an increased incidence of any (non-skin) cancer, whilst lower T was associated with an increased incidence of prostate cancer. No associations of androgens with lung cancer were observed; however, higher LH was associated with an increased risk of lung cancer. There were no associations of sex hormones with colorectal cancer incidence. Associations of low T and increased overall cancer risk may be reflective of poorer health status in these men. Further studies using LC-MS/MS-measured sex hormones are required to clarify the relationship between T and prostate cancer risk in men. Ongoing epidemiologic and mechanistic studies are required to validate findings of higher LH and lung cancer risk.