Low Testosterone Can Affect the Inner Structure of the Penis

Nelson Vergel

Founder, ExcelMale.com
Effects of testosterone supplementation on prevention of age-related penile remodeling.

Ferreira FT, et al.

Aging Male. 2014 Mar;17(1):12-7. doi: 10.3109/13685538.2013.873784. Epub 2014 Jan 7.


Abstract

Erectile dysfunction develops among 46.2% of men between 40 and 70 years. Studies demonstrated substitution on detrusor muscle by collagen due testosterone deprivation. It is clear the correlation among aging and oxidative stress, accelerating apoptosis process in many tissues. This study aims to demonstrate the collagen substitution over the muscle fibers on muscle structure of rat's penis and the effects of testosterone supplementation. Sixteen senescent Wistar rats were divided into two groups: treatment (receiving standard supplementation testosterone dose) and control (receiving equivalent saline solution). Testosterone was dosed on D0 and D56 of study. All penises were prepared with picrosirius colored histology; stereology was applied to determine the volumetric density of collagen fibers (Vv). Analysis of variance demonstrated testosterone group's replacement therapy to be effective, while the androgenic decline continued by the time of experiment in control group (p&#8201;<&#8201;0.05). Testosterone group had Vv of 20.6%, lower than control group (47.8%); t-test (p&#8201;<&#8201;0.001). Pearson's correlation demonstrated an inverse correlation between the Vv and testosterone's levels (p&#8201;<&#8201;0.001). This is a pioneer study on demonstration of structural alterations over the cavernous corpora muscle caused by deprivation of testosterone on elderly rat. These finding implicate that the testosterone levels can influence, not only the libido, but also the erectile function.
 
Yes you are absolutely right, but also androgen are important for the normal development of penis and their shortage results in structural abnormalities. Replacement of testosterone reverses these abnormalities.
 

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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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