Hi guys, I have been a very long lurker on this and other related forums. I am 31 years old male , been battling with low T all my life (more aware of it since 20 years old). Unfortunately I have never been able to experience any difference in my symptoms with all types of therapies , so i am non responder to TRT.
All my bloods are good , ruled out thyroid problems , insulin resistance etc, everything is good apart from SHBG which is very low ( around 7 without being on TRT) and testosterone usualy around 6. So i have tried every type of testosterone ester in different doses for different periods , tried HGH , tried some shady things that supposedly do not bind with SHBG (trestolone), been on keto for a long period, other diets , cleanses , supplements , you name it , nothing has worked. Made some sleep studies at 1 point to rule out sleep apnea, that wasnt the case as well. Another thing is that i have asthenozoospermia, so my chances are in vitro if at 1 point i want to go for kids.
Recently i decided to do a full genetic sequencing test (in my country they do it for a low amount for people with fertility problems) and finally I discovered that I have a genetic mutation since birth in the PROKR2 gene , which from my very scarce reading is a type of receptor , prokineticin 2 receptor site or something like that. I have a c.518 T>G mutation , I am not knowledgable on genetics at all , but the doctors say that usually this type of polymorphism is found in Kallman syndrome. I had a delayed puberty but still I have normal LH and FSH and male characteristics so I wouldnt say I fall in the category of Kallman syndrome.
The doctors mostly said that of course medicine is not developed enough so my genetic problem could be treated with gene therapy , but said i could try and tackle the symtoms with TRT .. which i been trying for a decade. They assume that since this genetic mutation is related with receptor sites , its possible that i have some type of peripheral androgen receptor resisntance.
I would appreciate any input , if someone has had the same case or maybe understands how this specific mutation is leading to TRT not having an effect to explain. Thank you.
All my bloods are good , ruled out thyroid problems , insulin resistance etc, everything is good apart from SHBG which is very low ( around 7 without being on TRT) and testosterone usualy around 6. So i have tried every type of testosterone ester in different doses for different periods , tried HGH , tried some shady things that supposedly do not bind with SHBG (trestolone), been on keto for a long period, other diets , cleanses , supplements , you name it , nothing has worked. Made some sleep studies at 1 point to rule out sleep apnea, that wasnt the case as well. Another thing is that i have asthenozoospermia, so my chances are in vitro if at 1 point i want to go for kids.
Recently i decided to do a full genetic sequencing test (in my country they do it for a low amount for people with fertility problems) and finally I discovered that I have a genetic mutation since birth in the PROKR2 gene , which from my very scarce reading is a type of receptor , prokineticin 2 receptor site or something like that. I have a c.518 T>G mutation , I am not knowledgable on genetics at all , but the doctors say that usually this type of polymorphism is found in Kallman syndrome. I had a delayed puberty but still I have normal LH and FSH and male characteristics so I wouldnt say I fall in the category of Kallman syndrome.
The doctors mostly said that of course medicine is not developed enough so my genetic problem could be treated with gene therapy , but said i could try and tackle the symtoms with TRT .. which i been trying for a decade. They assume that since this genetic mutation is related with receptor sites , its possible that i have some type of peripheral androgen receptor resisntance.
I would appreciate any input , if someone has had the same case or maybe understands how this specific mutation is leading to TRT not having an effect to explain. Thank you.