Low SHBG and High E/Free E.. Advice Needed

Long-time community lurker here. I am a 6'3 37-year-old male on TRT. I have been on TRT for 10 years and came off 4.5 years ago to conceive my now 3-year-old child. Since I have been back on (last 3.5 years), I have been struggling to dial in. Crashed my estrogen with anastrozole in September 2025 and a couple times before that. Before crashing, I was on 150mg test cyp once per week with some anastrozole use. Now, I inject testosterone cypionate every 3.5 days at 56mg per injection. I would like to stay away from AI’s from here on out if possible.

I am probably around 25% body fat but have decent muscle and strength. I lift weights 3-4 times a week and get roughly 10k steps a day. I am currently holding more fat in my chest and abdomen in the last month or so. My nipples are sensitive rarely, and the small gyno I have seems to be growing a little (I had removal surgery 14 months ago and the surgeon left some in to prevent cratering). My weight sometimes drops to 234-5 some mornings upon waking but for the most part is above 240, so it is fluctuating about 10 pounds throughout the week, which I believe is water retention. I am having some temporary anxiety and agitation. I do drink alcohol more than I should and I haven’t been eating well the last month or so. Here are my numbers from Quest on 4/25/2026, this blood work was taken 36 hours after injection.

Albumin 4.4

SHBG 14-17 (I don’t know why Quest gave two separate values)

Free testosterone 187-194.6 pg/ml

Testosterone Bioavailable 391.7

Total Testosterone 717-722 ng/dl

Hemoglobin 14.9

Hematocrit 45.5

Free Estradiol 1.22 pg/ml

Estradiol LC/MS 38-48 pg/ml (again, I don’t know why Quest gave two separate values)

Glucose 88 mg/dl


I have an appointment with my doctor in June (earliest availability), but I don’t want things to get any worse before then. Any input would be appreciated.
 

ExcelMale Newsletter Signup

Online statistics

Members online
2
Guests online
491
Total visitors
493

Latest posts

Beyond Testosterone Podcast

Back
Top