Low Sexual Desire in Men: Treatments & GLP-1 Impact

madman

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*This discussion explores why libido is frequently ignored and how it differs from arousal, performance, orgasm, and ejaculation. It highlights the brain as the primary sexual organ and explains how psychological factors such as stress, anxiety, depression, and chronic fatigue can significantly influence desire. Hormonal balance, particularly testosterone levels, also plays an important role, along with lifestyle factors and overall health.





In this podcast episode, we are joined once again by Dr. Rainey Horwitz, a first-year urology resident at Emory University School of Medicine. She’s passionate about sexual health and wellness and is dedicated to destigmatizing conversations about sex between patients and healthcare providers. As a returning guest, Dr. Horwitz brings fresh insights and clinical perspective to an evolving and often misunderstood topic: low sexual desire in men.

Low sexual desire in men is often misunderstood and overlooked, especially when compared to more visible concerns like erectile dysfunction. This discussion explores why libido is frequently ignored and how it differs from arousal, performance, orgasm, and ejaculation. It highlights the brain as the primary sexual organ and explains how psychological factors such as stress, anxiety, depression, and chronic fatigue can significantly influence desire. Hormonal balance, particularly testosterone levels, also plays an important role, along with lifestyle factors and overall health.


The conversation further examines emerging insights around GLP-1 medications, commonly used for weight loss and metabolic conditions, and their potential impact on sexual desire by affecting the brain’s reward and motivation systems. Overall, the topic emphasizes the need for better education, open communication between patients and providers, and a whole-person approach to male sexual health—recognizing libido as a dynamic, evolving experience rather than a problem to be ignored or oversimplified.
 
 
 
 
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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