Liver concerns on TRT?

bluerage · Jun 25, 2019

I've been on trt for the past 5 year. It took almost 2 years to get started because it was difficult to get doctors on board. During those pre TRT years I tried to gather as much info as I could.
Now a friend of my just started but he's concerned that testosterone is hard on the liver. I don't recall coming across anything supporting this. Does anybody here know if liver is a concern when using testosterone?

Sean Mosher · Jun 25, 2019

Not with injectables.
If you were to take an oral androgen of some sort then yes those are very hard on the liver.
No liver toxicity with TRT.

Vince Carter · Jun 25, 2019

Sean Mosher said:
Not with injectables.
If you were to take an oral androgen of some sort then yes those are very hard on the liver.
No liver toxicity with TRT.

Great post...100%

bluerage · Jun 25, 2019

Thanks for the reply. Like I said I didn't come across anything about the liver. I know that orals are harmful but he's adamant that even injectable T can cause elevated liver enzymes.

S1W · Jun 25, 2019

bluerage said:
I know that orals are harmful but he's adamant that even injectable T can cause elevated liver enzymes.

I have a couple of years worth of lab results that prove otherwise. No change in liver enzymes after 2.5 years on TRT.

Note that if part of your TRT protocol includes an AI, the AI may affect liver enzymes.

Cooper · Jun 27, 2019

what would be considered an oral androgen?

Sean Mosher · Jun 27, 2019

Anavar, Winstrol, Haloetc....

As far as I know the only one here in the US available under certain cirucmstances would be Oxandrolone (Anavar).
There's only mild liver toxicity with it though as long as it's reasonably dosed (that's my understanding).

Systemlord · Jun 27, 2019

My liver enzymes improved on TRT, my labs show a increase in liver enzymes a week after stopping TRT. As long as your testosterone levels are not low or in excess, good health is almost guaranteed as long as they are no other health problems.

Vince Carter · Jun 27, 2019

I too have a few years worth of normal AST/ALT liver tests while using injectables.

madman · Jun 27, 2019

bluerage said:
I've been on trt for the past 5 year. It took almost 2 years to get started because it was difficult to get doctors on board. During those pre TRT years I tried to gather as much info as I could.
Now a friend of my just started but he's concerned that testosterone is hard on the liver. I don't recall coming across anything supporting this. Does anybody here know if liver is a concern when using testosterone?

Esterified injectable testosterone is not known for causing any liver stress/toxicity.

If anything it is the c-17 alpha alkylated oral steroids such as android (methyltestosterone), oxandrolone (anavar), stanozolol (winstrol), methandrostenolone (dianabol), oxymetholone (anadrol 50), fluoxymesterone (halotestin)

Regarding c-17 alpha-alkylated orals and liver damage.....dose/duration/steroid play a significant role as to whether one would experience such negative effects.....let alone to what degree!