I suppose it is dependant on the individual, but I can tell you how HCG affects my labs (not sure tada will affect the labs). A couple of times I was due for labs, I had either ran out of hcg or it expired, so I was close to one week without it. My total T was 325 one visit and 500ish another visit. Free was 13.25 and 20.3. I was taking .25 anastrozole and 500iu HCG 3x per week (self reduced this to 300-400 bc of puffiness). Estrogen got too low so I stopped the ai completely. My next labs were with normal HCG routine - my free test was 23.5 and total was 585, and estrogen was over 50( not sure which E2 they used). I knew it was high bc I had the emotions of a pregnant woman lol. I feel like I am rambling but for me T dose kept constant at 85mg IM 1x week, hcg does affect mostly free T and E2, and 1-2 weeks off does affect my labs.