Ketamine's Role in Medicine: What You Need to Know

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Discover how ketamine, a well-established anesthetic, is gaining attention for its medical applications in anesthesia, pain management, and the treatment of psychiatric conditions. Learn about its method of action, interactions in pain pathways, and its use in managing treatment-resistant depression and PTSD. Stay informed about the potential benefits and risks of ketamine and its derivative, esketamine

 

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At certain dosages ketamine can induce hallucinations and dissociative effects such as an out of body sensation.

 

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Ketamine: A tale of two enantiomers

Abstract The discovery of the rapid antidepressant effects of the dissociative anaesthetic ketamine, an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is arguably the most important breakthrough in depression research in the last 50 years. Ketamine remains an off-label treatment for...

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Pharmacotherapy for Anhedonia

Pharmacological Treatments for Anhedonia (2022) Matthew E. Klein, Ariela Buxbaum Grice, Sahil Sheth, Megan Go, and James W. Murrough Abstract Anhedonia – the reduced ability to experience or respond to pleasure – is an important symptom domain for many psychiatric disorders. It is...

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Ketamine for the Treatment of MDD

https://www.hcplive.com/view/ketamine-for-the-treatment-of-mdd Ryan Oakley, MD, takes a closer look at the recent history of ketamine in depression. He also explores the differences between ketamine and esketamine.

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Depression — Advanced Treatments for Treatment-Resistant Depression

In this third episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine, Drs. Sanacora, Nikayin, and Cristancho discuss the role neuroplasticity may play in the pathogenesis of depression and the benefits to patients of advanced therapies for...

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