Is the Longevity Field Overhyped?

madman · 2025-11-02T13:02:52-0600

Eye opener!

22:56 Calling Out Hype

In this episode, I talk to Charles Brenner, a leading biochemist and outspoken critic of hype in the longevity field. We discuss why many aging studies in model organisms don’t always translate to humans, the limitations of current NAD-related therapies, and how publication bias harms scientific progress. He also shares what excites him most right now—his lab’s work on citrin deficiency and its potential for treating fatty liver disease and metabolic disorders.

Chapters

0:00 Intro
1:20 NAD Metabolism and Anti-Aging
5:20 Flawed Model Organisms
6:39 NAD Declines in Aging
13:30 Hype and Reality
22:56 Calling Out Hype
26:50 Negative Results in Science
28:34 Critiquing Bad Science
33:50 Academia Scandals
38:24 Longevity Clinical Trials
45:40 Advancements in the Field

madman · 2025-11-02T13:14:56-0600

Thread 'Diabetes, Obesity & Cancer: Dr. Charles Brenner Reveals the Metabolic Breakthroughs Transforming Men’s Health, Fatty Liver & GLP‑1 Therapy'

Today at 1:14 PM

In this episode of On the Edge of Breakthrough, host Dr. Monty Pal sits down with Dr. Charles Brenner, an internationally recognized expert in metabolism and the founding Chair of the Department of Diabetes & Cancer Metabolism at City of Hope. Together, they explore the metabolic links between diabetes, obesity, and cancer, and how understanding those connections could lead to new ways to prevent and treat multiple diseases.

Dr. Brenner shares insights from his research into lean fatty liver disease (otherwise known as metabolic dysfunction-associated...