Is My TRT Protocol Causing My Depression? Two Weeks on T-Cyp

From what I've read so far, Arimidex is usually introduced to the protocol around week 4 and not from the very beginning since it takes our bodies an equivalent amount of time to start raising estrogen levels. Maybe that's why .25/ week was a little too much for me.

No one should take an AI without labs, low estradiol levels, I believe is the biggest issue with TRT.
 
No one should take an AI without labs, low estradiol levels, I believe is the biggest issue with TRT.

So i got blood work few days ago on my trough day and results are as follow:

Testosterone 730 (348-1197)
Free Testosterone 18 (9.3-26.5)
DHEA Sulfate 325 (138.5 - 475.2)
TSH 2.51 (0.450 - 4.50)
t4 1.25 (.82 - 1.77)
Estradiol 18.2 (8.0- 35.0)
SHBG 23.6 (16.5- 55.9)

So Estradiol is lower than pre TRT ( 19.5 BEFORE ) When my testosterone level was also low ( 456 PRE trt). I was prescribed 0.125 armidex twice/week as a part of my protocol but I was only taking 1/week as I wasn't feeling good taking 2. I am considering cutting the AI completely and get another blood work in 2 Weeks, any thoughts on this?

I have a doctor appointment in 4 weeks from now but I really don't feel like I should wait any longer .
 
Last edited:
So i got blood work few days ago on my trough day and results are as follow:

Testosterone 730 (348-1197)
Free Testosterone 18 (9.3-26.5)
DHEA Sulfate 325 (138.5 - 475.2)
TSH 2.51 (0.450 - 4.50)
t4 1.25 (.82 - 1.77)
Estradiol 18.2 (8.0- 35.0)
SHBG 23.6 (16.5- 55.9)

So Estradiol is lower than pre TRT ( 19.5 BEFORE ) When my testosterone level was also low ( 456 PRE trt). I was prescribed 0.125 armidex twice/week as a part of my protocol but I was only taking 1/week as I wasn't feeling good taking 2. I am considering cutting the AI completely and get another blood work in 2 , any thoughts?

I have a doctor appointment in 4 weeks from now but I really don't feel like I should wait any longer .

You presented your test results, but didn't mention how you're feeling.
 
You presented your test results, but didn't mention how you're feeling.

I should have mentioned that first :)

Well I am not feeling much of the positive effect with TRT as I was hoping and expecting. I 've been on it for 11 weeks now and the first 3 weeks were the best of all but things started to fall apart one piece at a time.
-My energy level is low 2-3 days/week
-my mood and mental clarity are up and down , some days I would feel like finally TRT is working for me and some other days I would feel like crap
-Strength was going up the first few weeks but now it's going backward .
- Lipido the first 3 weeks was like If i was 18 years old, I was getting hard 24/7 and feeling so horny to the point I though I should call my doctor and see if I should reduce my dose..it was great though :) and my confidence was through the roof. Now ( although It's still MUCH better than before TRT). my lipido is up and down and I am back to using Cialis.

I really don't know if all of this can be related to E2 or not but something is not right for sure
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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