Is Metformin a Miracle Drug ? : Lecture

Nelson Vergel

Founder, ExcelMale.com
Jay Campbell invited me to present a review of relevant data on the use of Metformin in men with and without diabetes. I hope you enjoy the work I put into explaining the data to clarify the myths and facts about this old drug that is creating so much interest in the anti-aging world.

 
Metformin Reverses Established Lung Fibrosis
Researchers at the University of Alabama at Birmingham have shown — for the first time — that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism.

This novel finding, reported in the journal Nature Medicine, is important because, despite significant advances to reveal the pathological mechanisms of persistent fibrosis, effective treatment interventions are lacking.
 
Update from Nelson:

I now only use Metformin in cycles. After 3 weeks I can feel a dramatic reduction in stamina. It is unfortunate since my IBS symptoms are better on it (although it can make me constipated if I do not eat enough fiber). I get on the drug for cycles of 3 weeks and then take 2 weeks off.

Initially, I had body aches that were linked to an interaction with one of my medications. This problem subsided when I started consuming 5 grams per day of creatine monohydrate.

Click here for metformin related posts on ExcelMale
 
Lot of uncertainty still regarding efficacy for Covid. But, conincidentally, I've just started taking Metformin for anti-aging (supposed) effects even though I'm not diabetic. 500mg/d in pm. Only, 4 doses in so far.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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