is 0.25 mg arimidex twice a week too much ?

eudes · May 28, 2018

my E2 are 40-45 pg/ ml and I need to reduce them to the 20 pg range
IS 0.25 mg adex twice a week too much ?
IS it better to start with 0.125 mg twice a week ? or 0.25 mg ONCE a week ?
thanks

Gman86 · May 28, 2018

When I ran 0.25mg EOD of Arimidex it pretty much crashed my E2. It was at 9 on the sensitive test. It's definitely strong stuff. You definitely want to err on the side of caution with ai's. I personally would do something like 0.125mg E3d and see how that goes. And then if that's not enough try 0.125mg EOD, which would equal out to about 0.5mg/ week.

Sean Mosher · May 29, 2018

Are you 100% sure you feel your best at the 20pg/ml mark?
If that's not using the sensitive LC/MS measurement then you're going to be running low on estradiol.

Vince Carter · May 29, 2018

eudes said:
my E2 are 40-45 pg/ ml and I need to reduce them to the 20 pg range
IS 0.25 mg adex twice a week too much ?
IS it better to start with 0.125 mg twice a week ? or 0.25 mg ONCE a week ?
thanks

Need more info, and, no one can tell you how X dose will reduce any one's E. Most any of us are going to ask why you need your E reduced because inb most instances 40-45 isn't going to be all that high

eudes · May 29, 2018

because i am taking finasteride for hair loss , and the increase of E2 is enough to cause me gynecomastia ( puffy nipples / lump )

WrenchHead80 · May 29, 2018

I'm new here myself but I think more info would help others help you.

How much T or you doing a week and are you doing it with one or more shots?

You testing your E with regular or sensitive test?

You taking HCG? If so how much a week? One dose or multi a week? HCG cause E spikes.

Whats your SHBG? If your low SHBG your more likely to have more E in your system that needs to be taken care of and hence need a little more AI.

FYI: I take three shots a week of 50mg test c and three shots of 330ius of HCG a week and require two .25 AI pills a week Mon and Thur. I'm also low SHBG. Defy said my blood work looked great at the protocol I'm doing but said guys usually do two .125 AI pills a week but I should stay with what I'm doing. I'm assuming my low SHBG is causing more free E and my larger .25 dose of AI keeps it in check, hence why I haven't crashed my E.

Systemlord · May 29, 2018

eudes said:
because i am taking finasteride for hair loss , and the increase of E2 is enough to cause me gynecomastia ( puffy nipples / lump )

The Finasteride alone is enough to cause gynecomastia, are you aware of the dangers of taking Finasteride known as Finasteride Syndrome?

Finasteride can cause HPTA disruption sending E2 skyrocketing.

Vince · May 29, 2018

Finasteride is a synthetic 5-alpha reductase inhibitor, which prevents the conversion of testosterone to dihydrotestosterone and has been used for more than 20 years in the treatment of male pattern hair loss. Randomized, controlled trials have associated finasteride with both reversible and persistent adverse effects. In this pilot study, we sought to characterize sexual and nonsexual adverse effects that men reported experiencing at least 3 months after stopping the medication. Based on previous research on persistent side effects of finasteride, we constructed an Internet survey targeting six domains: physical symptoms, sexual libido, ejaculatory disorders, disorders of the penis and testes, cognitive symptoms, and psychological symptoms and was e-mailed to patients who reported experiencing symptoms of side effects of finasteride. Responses from 131 generally healthy men (mean age, 24 years) who had taken finasteride for male pattern hair loss was included in the analysis. The most notable finding was that adverse effects persisted in each of the domains, indicating the possible presence of a "post-finasteride syndrome."
https://www.excelmale.com/content.p...ide-Syndrome-Persistent-Propecia-Side-Effects

madman · May 30, 2018

Vince said:
Finasteride is a synthetic 5-alpha reductase inhibitor, which prevents the conversion of testosterone to dihydrotestosterone and has been used for more than 20 years in the treatment of male pattern hair loss. Randomized, controlled trials have associated finasteride with both reversible and persistent adverse effects. In this pilot study, we sought to characterize sexual and nonsexual adverse effects that men reported experiencing at least 3 months after stopping the medication. Based on previous research on persistent side effects of finasteride, we constructed an Internet survey targeting six domains: physical symptoms, sexual libido, ejaculatory disorders, disorders of the penis and testes, cognitive symptoms, and psychological symptoms and was e-mailed to patients who reported experiencing symptoms of side effects of finasteride. Responses from 131 generally healthy men (mean age, 24 years) who had taken finasteride for male pattern hair loss was included in the analysis. The most notable finding was that adverse effects persisted in each of the domains, indicating the possible presence of a "post-finasteride syndrome."
https://www.excelmale.com/content.p...ide-Syndrome-Persistent-Propecia-Side-Effects

Before one is set on whether dht suppression from the use of 5-alpha reductase inhibitors looking at the overall picture is key.

Here is an RDC using the potent dutasteride which is a type I and II 5-alpha reductase inhibitor as oppose to finasteride which is only a type II inhibitor.