Interview: Clomid for TRT-Clomiphene Citrate and Enclomiphene for LOW Testosterone

Hi Nelson, great video, thanks! I have a question you didn't really cover. Is clomiphene effective at simply preventing testicular atrophy while on TRT?

When I started TRT I only added HCG for that reason, my testicles were aching and I didn't want them to atrophy. Libido and everything else was good on just T. So I'm just looking for a replacement for HCG to keep them functioning since our HCG supply is going away.
 
Unfortunately, clomiphene does not seem to revert or prevent testicular atrophy.
The exception is if you bypass the hypothalamus by co-administering GnRH. Most will find this impractical, but it does work to prevent atrophy, likely even better than hCG due to production of FSH in addition to LH:
 
Thanks Nelson! I do know it's still available, but the price is many times higher.

Oh, I just clicked your link for coupons, that's a good price! My Dr. stocked up and has their own supply for now, but when that runs out I'll try goodrx again. Thanks!
 
I bet all my money that the price of hCG from regular pharmacies will go up dramatically when compounding pharmacies stop making it completely.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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