My PSA has gone from 2.5 in May of 2014 to 3.8 in Feb. This roughly coincides with when I started injections. My primary noted a concern, my test clinic said we need to watch it and today a new clinic I am investigating says they won't touch me with that level. I am going to make an appointment with my urologist as I understand there can be several reasons for the elevation. Is this level of elevation common with TRT?
John - I don't think I'd be overly concerned if I were you. Yes, talk with a competent urologist, one who sees the benefits of TRT (believe me, not all do). That increase in PSA can be do to several things. Doc may not even be too comcerned unless it gets over 5 or maybe your urologist will look at the % increase, I don't know. I think it's not uncommon for PSA to rise initially and then slowly settle back to where it was at baseline.
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
