Increased Myocardial Infarction Risk from TRT? Dr Saya, Dr Crisler, Jasen, Nelson, thoughts?

Read this research abstract today on increased risk of non-fatal myocardial infarction following the start of a TRT regimen , and wanted to see if the community had any thoughts, positive or negative, on the results.

Abstract link - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085805

Would be very very interested in hearing thoughts from Dr Saya, Dr Crisler, Jasen and Nelson.

Old news, was published over 2 years ago and was part of the ambulance chasing attorney TV commercials you likely saw pop up around that time.

I've, quite literally, spent 100 hours or more answering patient questions and counseling on this very topic, so forgive if I seem a bit terse on the subject. The data has been discussed (and discredited) thoroughly. I agree with Coastwatcher, Nelson has compiled some good info on the topic.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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