I was wondering if any members use L plantarum PS128 for mental health?

[Vince]

Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders​

PS128 is a novel psycho biotic strain, it has been reported to play an important role in neuropsychiatric disorders. This study investigated the clinical effect of PS128 supplementation on patients with anxiety.

Methods​

A total of 200 patients with anxiety were recruited, and divided into two groups (n = 100/group). The control group received oral treatment with citalopram, and the PS128 group received PS128 capsules based on citalopram treatment. Hamilton Anxiety Scale (HAMA) and Self-Rating Anxiety Scale (SAS) were used to evaluate the anxiety levels. After 2 months of continuous administration, clinical efficacy was evaluated according to HAMA score.

Results​

There was no significant difference in HAMA and SAS scores between the two groups before treatment. With the treatment prolonged, the HAMA and SAS score decreased gradually in both control and PS128 groups, and the decrease rate of PS128 group was significantly greater than that of the control group. The clinical effective rates of PS128 group were higher than those in the control group, high levels of clinical cure rate were also detected in the PS128 group. Compared with the control group (22%), the incidence of adverse reactions was significantly reduced for patients in the PS128 group (4%).

Conclusion​

The treatment effect of citalopram combined with PS128 against anxiety is satisfactory clinically. It can greatly improve the anxiety symptoms of patients, increase the cure rate, reduce adverse reactions.

Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders

PS128 is a novel psycho biotic strain, it has been reported to play an important role in neuropsychiatric disorders. This study investigated the clinical effect of PS128 supplementation on patients with anxiety.A total of 200 patients with anxiety were ...

www.ncbi.nlm.nih.gov

 

[Vince]

The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson's Disease: A Pilot Study​

Background: Lactobacillus plantarum PS128 (PS128) is a specific probiotic, known as a psychobiotic, which has been demonstrated to alleviate motor deficits and inhibit neurodegenerative processes in Parkinson's disease (PD)-model mice. We hypothesize that it may also be beneficial to patients with PD based on the possible mechanism via the microbiome-gut-brain axis.

Methods: This is an open-label, single-arm, baseline-controlled trial. The eligible participants were scheduled to take 60 billion colony-forming units of PS128 once per night for 12 weeks. Clinical assessments were conducted using the Unified Parkinson's Disease Rating Scale (UPDRS), modified Hoehn and Yahr scale, and change in patient “ON-OFF” diary recording as primary outcome measures. The non-motor symptoms questionnaire, Beck depression inventory-II, patient assessment of constipation symptom, 39-item Parkinson's Disease Questionnaire (PDQ-39), and Patient Global Impression of Change (PGI-C) were assessed as secondary outcome measures.

Results: Twenty-five eligible patients (32% women) completed the study. The mean age was 61.84 ± 5.74 years (range, 52–72), mean disease duration was 10.12 ± 2.3 years (range, 5–14), and levodopa equivalent daily dosage was 1063.4 ± 209.5 mg/daily (range, 675–1,560). All patients remained on the same dosage of anti-parkinsonian and other drugs throughout the study. After 12 weeks of PS128 supplementation, the UPDRS motor scores improved significantly in both the OFF and ON states (p = 0.004 and p = 0.007, respectively). In addition, PS128 intervention significantly improved the duration of the ON period and OFF period as well as PDQ-39 values. However, no obvious effect of PS128 on non-motor symptoms of patients with PD was observed. Notably, the PGI-C scores improved in 17 patients (68%). PS128 intervention was also found to significantly reduce plasma myeloperoxidase and urine creatinine levels.

Conclusion: The present study demonstrated that PS128 supplementation for 12 weeks with constant anti-parkinsonian medication improved the UPDRS motor score and quality of life of PD patients. We suggest that PS128 could serve as a therapeutic adjuvant for the treatment of PD. In the future, placebo-controlled studies are needed to further support the efficacy of PS128 supplementation.

Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT04389762.

The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson's Disease: A Pilot Study

Background: Lactobacillus plantarum PS128 (PS128) is a specific probiotic, known as a psychobiotic, which has been demonstrated to alleviate motor deficits and inhibit neurodegenerative processes in Parkinson's disease (PD)-model mice. We hypothesize ...

www.ncbi.nlm.nih.gov

 

[Vince]

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, improves motor function, depression, and anxiety ...

www.ncbi.nlm.nih.gov

 

[Vince]

AI Overview
Yes, Lactobacillus plantarum PS128 (PS128) may help improve sleep quality and decrease depressive symptoms:

	Benefits
Sleep	May improve sleep quality, especially during deep sleep
Mood	May improve mood and reduce negative emotions
Stress	May improve stress and anxiety
Other	May reduce fatigue and cortical excitation

PS128 is a probiotic that may help people sleep better and improve their mood by interacting with the gut and brain. The gut-brain axis is a bidirectional link between the gut microbiota and the central nervous system, which may regulate the sleep-wake cycle. Some research suggests that the wrong types of microbes in the gut can lead to disordered serotonin transportation, which may contribute to sleep disorders.


A clinical study found that participants who took PS128 daily for eight weeks reported significant improvements in sleep quality, anxiety, job stress, and more.


Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep ...
Aug 17, 2021 — These findings suggest that daily administration of PS128 may lead to a decrease in depressive symptoms, fatigue level, cortical excitation, and an .

Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Recent animal studies have supported that Lactobacillus plantarum PS128 (PS128) can reduce the severity of anxiety and depression. However, previous studies did not focus on the sleep quality and mood of humans. This study determines whether PS128 reduces ...

www.ncbi.nlm.nih.gov

 

[DixieWrecked]

Wow that's very cool. I hope we got some guys that have experimented

 

[Seagal]

I wouldn't know where to get this particular strain.

 

[Vince]

I wouldn't know where to get this particular strain.

I ordered some. 60 tablets, with the shipping the cost is just under $140, crazy expensive.

 

[Seagal]

I ordered some. 60 tablets, with the shipping the cost is just under $140, crazy expensive.

Many of us would greatly appreciate if you would report about your experience with it; assuming you ordered for yourself.

 

[DixieWrecked]

I ordered some. 60 tablets, with the shipping the cost is just under $140, crazy expensive.

Where did you order it from? Haven't had much luck with googling.

 

[Vince]

Where did you order it from? Haven't had much luck with googling.

Fashion For Your Eyes by Couture Fashion source

 

[Vince]

Many of us would greatly appreciate if you would report about your experience with it; assuming you ordered for yourself.

I will report back when I get my results

 

[Vince]

Lactiplantibacillus plantarum PS128 - Wikipedia

en.m.wikipedia.org

 

[Vince]

Parkinson’s disease: New study shifts focus from brain to early gastrointestinal symptoms

“Many people who get Parkinson’s disease experience GI symptoms like constipation and nausea for years -- even decades -- prior to developing motor symptoms like difficulty walking or tremors,” said corresponding author Trisha S. Pasricha.

indianexpress-com.cdn.ampproject.org

 

[Vince]

I've been taking one capsule daily (recommended dose is 2) now for a little over 2 weeks. According to my Fitbit my deep sleep and REM sleep have definitely improved.

Could be placebo, I'll continue taking and see if my results continue.

 

[DixieWrecked]

keep us posted, man. Thank you!

 

[Vince]

The end of October I increased my dose to two a day. I'm not sure if my sleep has improved. I am keeping track on my sleep through my Fitbit watch.

 

[Vince]

You may not think much about your dreams, other than occasionally wondering what they mean. But dreams are an important part of a sleep stage known as REM sleep. All sleep is important, but REM sleep plays a key role for brain health and function.

REM sleep: What is it, why is it important, and how can you get more of it? - Harvard Health

Explore the importance of REM sleep for good cognitive and physical health. Learn strategies for sleeping more soundly....

www.health.harvard.edu

 

[DixieWrecked]

The probiotics affecting your dreams?

 

[Vince]

It seems to be improving both my REM and deep sleep. Only time will tell for sure.