Rachel Rubin, MD a urologist and sexual medicine specialist, discusses the critical need for physician and public engagement with the FDA on women's health. Learn how to advocate for the removal of inaccurate boxed warning labels on vaginal hormone therapies.
Dr. Rubin highlights the immense benefits and safety of vaginal estrogen and DHEA for treating genitourinary syndrome of menopause (GSM). She explains how these local therapies can prevent serious conditions like urinary tract infections and improve sexual health, dispelling common misconceptions and emphasizing the lack of evidence supporting the current warning labels. This episode is a call to action for all healthcare professionals, including primary care physicians, cardiologists, and oncologists, to confidently prescribe these life-saving medications. Get involved and share your voice to help save lives and transform the future of women's health.
This was a very important meeting with top experts that are trying to change guidelines. This FDA panel recently recommended removing the warning (“black box”) labels on menopausal HRT, citing potential benefits like reduced heart attack and bone fracture risk—and arguing the warning discourages appropriate use.
Hopefully, we will see progress in this field after the confusing and sometimes misleading conclusions of the WHI (“Women’s Health Initiative”), a large National Institutes of Health trial...
Dr. Rachel Rubin outlines how simple, low-dose vaginal estrogen—backed by the 2025 AUA GSM guideline—can prevent recurrent UTIs, relieve symptoms, and save lives. A must-watch for providers treating menopausal patients.
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
