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Hormonal stimulation of spermatogenesis: a new way to treat the infertile male with non-obstructive azoospermia?
Rita J. Laursen · Helle O. Elbaek · Betina B. Povlsen · Jette Lykkegaard · Kirsten B. S. Jensen · Sandro C. Esteves · Peter Humaidan
We herein report a full-term delivery of a healthy child obtained with aid of intracytoplasmic sperm injection (ICSI) in an infertile couple with non-obstructive azoospermia (NOA) and severe endometriosis, following hormonal stimulation of spermatogenesis, cryopreservation of ejaculated spermatozoa using the cell sleeper method, and subsequently ICSI.
Conclusions
This report describes successful hormonal stimulation of spermatogenesis in a non-obstructive azoospermic male, in whom individual spermatozoa were frozen on cell sleepers. With this procedure, the couple subsequently obtained a live birth after their first ICSI embryo transfer. Although more cases are needed to draw conclusions, we suggest that the combination of male hormonal stimulation, the cell sleeper method, and ICSI treatment might give new hope for biological parenting in such couples, who would otherwise be referred to either sperm donation or adoption.
Rita J. Laursen · Helle O. Elbaek · Betina B. Povlsen · Jette Lykkegaard · Kirsten B. S. Jensen · Sandro C. Esteves · Peter Humaidan
We herein report a full-term delivery of a healthy child obtained with aid of intracytoplasmic sperm injection (ICSI) in an infertile couple with non-obstructive azoospermia (NOA) and severe endometriosis, following hormonal stimulation of spermatogenesis, cryopreservation of ejaculated spermatozoa using the cell sleeper method, and subsequently ICSI.
Conclusions
This report describes successful hormonal stimulation of spermatogenesis in a non-obstructive azoospermic male, in whom individual spermatozoa were frozen on cell sleepers. With this procedure, the couple subsequently obtained a live birth after their first ICSI embryo transfer. Although more cases are needed to draw conclusions, we suggest that the combination of male hormonal stimulation, the cell sleeper method, and ICSI treatment might give new hope for biological parenting in such couples, who would otherwise be referred to either sperm donation or adoption.
