PAUL-E
Member
Folic acid is a type of B vitamin. It is the synthetic form of folate that is found in supplements and added to fortified foods. Folate is a generic term for both naturally occurring folate found in foods and folic acid. Folic acid is not stored in the body and you need a continuous supply of the vitamin in the foods you eat. Folate occurs naturally in dark green leafy vegetables, dried beans and peas (legumes), citrus fruits and juices.
One of the most important uses of folate in the body, is as a precursor of methyl groups. Methyl groups are needed for many biochemical reactions in the body, and also for turning genes on and off. (Epigenetics)
The MTHFR gene encodes an enzyme that is critical in the metabolism of folate. People who are deficient in this enzyme are unable to convert folic acid to its active forms in the body, and as a result, have a build up of toxic by-products such as Homocysteine, which has been associated with heart disease and dementia.
Reduced function of this MTHFR gene prevents people from converting dietary folate or supplemental folic acid into active forms. It also causes higher levels of homocysteine which is associated with diseases such as stroke, vascular dementia and coronary artery disease.
Supplementation with L5-Methyl Folate has been shown to lower homocysteine by 15% in those affected by MTHFR C677T rs1801133.
Supplementation with Vitamin B12 and Vitamin B2 are also useful because, Methyl cobalamin (a form of Vitamin B12) is a cofactor of methionine synthetase which converts homocysteine to methionine. RIboflavin (Vitamin B2) is a cofactor of MTHFR, stabilizing the enzyme and increasing its efficiency.
https://livewello.com/health-reports/folate-and-the-mthfr-gene
So basically if your homocysteine levels are high it might be worth trying to supplement with L5-MethylFolate and b12 and b2 might increase its efficiency.
One of the most important uses of folate in the body, is as a precursor of methyl groups. Methyl groups are needed for many biochemical reactions in the body, and also for turning genes on and off. (Epigenetics)
The MTHFR gene encodes an enzyme that is critical in the metabolism of folate. People who are deficient in this enzyme are unable to convert folic acid to its active forms in the body, and as a result, have a build up of toxic by-products such as Homocysteine, which has been associated with heart disease and dementia.
Reduced function of this MTHFR gene prevents people from converting dietary folate or supplemental folic acid into active forms. It also causes higher levels of homocysteine which is associated with diseases such as stroke, vascular dementia and coronary artery disease.
Supplementation with L5-Methyl Folate has been shown to lower homocysteine by 15% in those affected by MTHFR C677T rs1801133.
Supplementation with Vitamin B12 and Vitamin B2 are also useful because, Methyl cobalamin (a form of Vitamin B12) is a cofactor of methionine synthetase which converts homocysteine to methionine. RIboflavin (Vitamin B2) is a cofactor of MTHFR, stabilizing the enzyme and increasing its efficiency.
https://livewello.com/health-reports/folate-and-the-mthfr-gene
So basically if your homocysteine levels are high it might be worth trying to supplement with L5-MethylFolate and b12 and b2 might increase its efficiency.
