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madman

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Study shows patients have a positive perception of testosterone nasal gel


Urologists and patients may have preconceived notions when it comes to acceptance and usability of various replacement testosterone therapies (TTh). We make assumptions that men will prefer a needle over a patch or a topical gel over a nasal gel. When Natesto® testosterone nasal gel (TNG) was introduced in Canada, we all weren’t too sure how it would be accepted. We presumed that nasal administration and twice daily (bid) to three times daily (tid) dosing would either be a big deal, leading to resistance by patients or no big deal, leading to widespread adoption. The truth is, beyond anecdote, we haven’t really examined patient preference of TNG vs. topical TTh. The My-T study in this month’s issue of CUAJ sheds some light on this subject in both novice and experienced users of replacement TTh.








What is interesting in this study is that patients, the majority of whom were prior testosterone users (experienced), perceived TNG to be more effective and convenient despite the more frequent dosing schedule than the available alternatives. Patient compliance to treatment is an issue that plagues clinical care. The concern that bid or tid dosing will lead to patient dissatisfaction was not demonstrated in this study. In fact, this study sheds positive light on TNG from the practical viewpoint of the patient. It would be interesting to see if this translates into a change in prescribing patterns by both urologists and primary care providers at large.
 

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hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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