Help w/ labs and my E2

Retest in 6 months. Your E2 is fine. As long as u don’t have symptoms u shouldn’t worry about E2 at all even if it was at 90. Do u have extremity swelling? Gynomastica? Lumps in your nipples? Breast enlargement? If not move on and stop worrying about E2. It’s about how u feel. High E2 is better than too low. Your body needs estrogen and the higher your testosterone goes u will need more estrogen. Too much testosterone and not enough estrogen is no good. Your body’s endocrine system is doing its job.
 
Retest in 6 months. Your E2 is fine. As long as u don’t have symptoms u shouldn’t worry about E2 at all even if it was at 90. Do u have extremity swelling? Gynomastica? Lumps in your nipples? Breast enlargement? If not move on and stop worrying about E2. It’s about how u feel. High E2 is better than too low. Your body needs estrogen and the higher your testosterone goes u will need more estrogen. Too much testosterone and not enough estrogen is no good. Your body’s endocrine system is doing its job.
No I do not have any of those symptoms. I may just get my free testosterone test it again as it was noted I did the wrong test.
 
... I may just get my free testosterone test it again as it was noted I did the wrong test.
I wouldn't go out of my way to get that test. Just add it next time. In the meantime you have the data to calculate free testosterone. These calculations certainly aren't perfect, but they do correlate pretty well with the accurate tests.

The granddaddy of calculations is the Vermeulen method. The value in your case is 24 ng/dL. Average for young men is around 15. Guys may start having symptoms of low T when this free T value goes below 10.

Tru-T is a newer calculation, and your value is 32 ng/dL, with a healthy normal range considered to be 16-31 ng/dL.

The bottom line is that your free testosterone is a little on the high side, so you could reduce your testosterone dose by up to 20% and still have above-average levels. This would lower estradiol and reduce the risk of TRT-related side effects.

I don't agree with the idea that exceptionally high estradiol—e.g. 90 pg/mL—is nothing to worry about as long as it's balanced by testosterone. Nobody can say this with certainty. At best, maintaining high levels long-term is an experiment, and your health is dependent on the outcome.
 
Hey all, can you help me with my test results. I’m currently on 30mg EOD of test cyp. I just changed from e3.5d to EOD 2 months ago to see if it will help me feel better. I was a little sluggish so I tried the change.

My E2 was always in the 16-22 range and now it’s jumped to 45. Nothing else really changed. How does everything else look and any tips why e2 went so high?
Is your testosterone from a pharmacy or ugl? If it’s prescribed is it compounded or a big pharma brand? If it’s ugl or compounded there could be a chance the dosing is a bit off from your last labs
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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