HCG Monotherapy Risks

Somedude20

New Member
Hello,

I am a 29 year old male, fit with low bodyfat and decent muscle mass (if that matters). I have a prescription for HCG Monotherapy that I am still deciding whether or not to use. Before anyone asks, I have no desire for TRT at this stage in life due to it permanently shutting down testosterone function.

My question is: If I decide to try the HCG monotherapy and months down the line get tired of injecting everyday.

1.) What are the immediate side effects of coming off?
2.) Will it mess with my pituitary function long term?
3.) Will my hormone levels return to pre-HCG monotherapy after ceasing, and if yes, how long until that occurs?

Thank you in advance, I'm excited to about feeling better just want to make sure it's a good fit long term.
 
HCG will increase your testosterone while keeping your testicles working, but it really acts like testosterone therapy. Its use shuts down LH and FSH. When you stop HCG you may or may not return back to where you are now. I think it is not a bad idea to start it at 500 IU every other day or probably 1000 IU twice a week. Retest 6 weeks later for TT, FT and E2 by ultrasensitive test. https://www.excelmale.com/forum/sho...e-Testicular-Shrinkage-and-Preserve-Fertility
 
Before anyone asks, I have no desire for TRT at this stage in life due to it permanently shutting down testosterone function.
It's a bit more complex, your HPTA will be shutdown on HCG and testicular function will be preserved, but HCG only stimulates half of the testicles while suppressing the other half.

The shutdown that occurs on TRT is usually temporary until one ceases TRT, so typically it's not permanently unless things were already headed in that direction.

I stopped TRT in 2019 for a short time and four and a half weeks later my natural production fired up again.
 
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It's a bit more complex, your HPTA will be shutdown on HCG and testicular function will be preserved, but HCG only stimulates half of the testicles while suppressing the other half.

The shutdown that occurs on TRT is usually temporary until one ceases TRT, so typically it's not permanently unless things were already headed in that direction.

I stopped TRT in 2019 for a short time and four and a half weeks later my natural production fired up again.

Not interested in T at this time, I know that doesn't make sense but I'm just not comfortable with it. Is the answer for the HCG shutting you down, we don't know?
 
Could you persuade your provider to let you try enclomiphene first? This drug stimulates the entire HPTA.

Subjective results with hCG monotherapy are notoriously poor; success stories are not so common. Estradiol management is often a problem. Oftentimes guys are simply tolerating the treatment long enough to get a partner pregnant.
 
Hello,

I am a 29 year old male, fit with low bodyfat and decent muscle mass (if that matters). I have a prescription for HCG Monotherapy that I am still deciding whether or not to use. Before anyone asks, I have no desire for TRT at this stage in life due to it permanently shutting down testosterone function.

My question is: If I decide to try the HCG monotherapy and months down the line get tired of injecting everyday.

1.) What are the immediate side effects of coming off?
2.) Will it mess with my pituitary function long term?
3.) Will my hormone levels return to pre-HCG monotherapy after ceasing, and if yes, how long until that occurs?

Thank you in advance, I'm excited to about feeling better just want to make sure it's a good fit long term.



 


 
Could you persuade your provider to let you try enclomiphene first? This drug stimulates the entire HPTA.

Subjective results with hCG monotherapy are notoriously poor; success stories are not so common. Estradiol management is often a problem. Oftentimes guys are simply tolerating the treatment long enough to get a partner pregnant.
$$$
 
Could you persuade your provider to let you try enclomiphene first? This drug stimulates the entire HPTA.

Subjective results with hCG monotherapy are notoriously poor; success stories are not so common. Estradiol management is often a problem. Oftentimes guys are simply tolerating the treatment long enough to get a partner pregnant.
A while ago I took Clomid but the libido went down there.
 
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Is the answer for the HCG shutting you down, we don't know?

your HPTA will be shutdown on HCG and testicular function will be preserved.
It's already been answered. So basically if you decide to start HCG mono, your HPTA will get shutdown and LH stimulation will cease. HCG will mimic LH and stimulate your testicles to produce testosterone.

If you decide to stop HCG mono, as with TRT there will likely be several weeks before your pituitary gland fires back up again to stimulate testosterone production again.
 
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It's already been answered. So basically if you decide to start HCG mono, your HPTA will get shutdown and LH stimulation will cease. HCG will mimic LH and stimulate your testicles to produce testosterone.

If you decide to stop HCG mono, as with TRT there will likely be several weeks before your pituitary gland fires back up again to stimulate testosterone production again.
At what dosage does HCG block the HPTA axis?
 

hCG Mixing Calculator

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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