Other then his position on E2 with TRT which I disagree with, among others; this guy knows his shit!!! Note the 50 mg daily BUT with Slow Release...very important do to the fast half life of the drug. Or the alternative would be 25 mg twice daily of a non SR.
DHEA Supplementation
Dehydroepiandrosterone: DHEA
As presented by Dr. Neal Rouzier, M.D.
DHEA is a hormone secreted primarily by the adrenal glands. It results in a shift of a catabolic state to an anabolic or protein building state.
• It reduces cardiovascular risks by increasing lipolyses (decrease visceral fat).
• It stimulates the immune system, restores sexual vitality, improves moods, decreases cholesterol and body fat.
• It improves memory, increases energy, and has anti-cancer properties by enhancing the immune system.
• It is an endocrine precursor to other hormones, prevents immuno-senescence, loss of sleep, osteoporosis, atherosclerosis.
• DHEA reduces insulin requirement
• Adrenal hormone anabolic vs. catabolic metabolism
• Restores immunity
• Prevents osteoporosis, increases bone density
• Prevents cancer in lab animals
• Prevents diabetes & heart disease
• Decreases visceral fat
• Improves mood & well-being
• Improves energy & memory
• Slows aging process in lab animals
• Prevents lipid peroxidation = antioxidant
• Endocrine precursor to T.P.E.
• 7-keto DHEA is not a precursor to other HRT = avoid
• Neurotransmitter (recently discovered)
• Presently pending FDA approval for Lupus (Prasterone)
Clinically substantiated uses of DHEA include replacement for:
• Low DHEA levels
• Chronic disease
• Adrenal exhaustion or corticosteroid therapy
• SLE
• Improving bone density
• Improving depression & mood disorders
• Enhancing immune response by activating T-cells
• Improving well-being
• Decreasing cardiovascular risk
• Improving erectile dysfunction
• Anyone over 40
• DHEA has never been shown to reverse the aging process
• Nevertheless DHEA is important for preventive medicine
• DHEA inhibits synthesis of thromboxane A2, reduces plasminogen activator inhibitor, and tissue plasminogen activator – all decreasing platelet aggregation and ischemia.
Administration:
Men<200lb: 50mg AM
Men>200lb: 75-100mg AM
Women <50yo: 10-15mg AM
Women >50yo: 25mg AM
IMPORTANT:
DHEA Serum Levels
MEN
• Range 100-600
• Optimal 500-600
WOMEN
• Range 50-300
• Optimal 200-250
Higher levels in women predispose them to side effects – therefore stay low.
• Monitor monthly until optimal
• Assure correct dose and compliance
• Measure DHEA-S and not DHEA
• Side effects: acne, hirsutism
• Tx: Lower dose or take QOD Spironolactone 100 mg/day
• Contraindicated in sex hormone responsive tumors – breast, ovarian, uterine, prostate
• Conversion to T.P.E.?
• DHEA raises testosterone levels in women slightly, yet not in men
• DHEA raises estradiol slightly in men
Indications:
• Over age 40 for health protection
• Preventive medicine and well-being
• Symptoms of aging, mood & depression
• Cause the medical literature suggests it if we want to live longer, happier, healthier
DHEA – S
MEN Blood levels
• Optimal : 500-600 ug/ml
• Side effects rare in men
WOMEN Blood Levels
• Optimal : 200-250 ug/ml
• Dose based on side effects
• Side effects very common in women
DHEA Dose
MEN
• Capsule – SR micronized
• 50 mg Q am
• >200 lbs – 75 - 100 mg Q am
WOMEN
• Capsule – SR micronized
• 10 mg Q am if over 40
• 15 mg Q am if over 50
• 25 mg Q am if over 60
• If under age 40, do not prescribe due to sensitivity causing side effects.
Gene, I read your post but didn't see where he reccomends what form of DHEA unless I missed something? Capsule I presume?
