Harvard Calls for Retraction of Dozens of Studies by Noted Cardiac Researcher

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Some 31 studies by Dr. Piero Anversa contain fabricated or falsified data, officials concluded. Dr. Anversa popularized the idea of stem cell treatment for damaged hearts.

Oct. 15, 2018
A prominent heart researcher formerly at Harvard Medical School and Brigham and Women’s Hospital in Boston fabricated or falsified data in 31 published studies that should be retracted, officials at the institutions have concluded.

The scientist, Dr. Piero Anversa produced research suggesting that damaged heart muscle could be regenerated with stem cells, a type of cell that can transform itself into a variety of other cells.
Although other laboratories could not reproduce his findings, the work led to the formation of start-up companies to develop new treatments for heart attacks and stroke, and inspired a clinical trial funded by the National Institutes of Health.
“A couple of papers may be alarming, but 31 additional papers in question is almost unheard-of,” said Benoit Bruneau, associate director of cardiovascular research at the Gladstone Institutes in San Francisco. “It is a lab’s almost entire body of work, and therefore almost an entire field of research, put into question.”

Harvard Calls for Retraction of Dozens of Studies by Noted Cardiac Researcher
 

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Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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