GLP-1s, Muscle Loss, & Midlife Metabolism: What Women Really Need to Know

madman

Super Moderator

In this episode of You Are Not Broken, Dr. Kelly Casperson sits down with endocrinologist and obesity medicine expert Dr. Rocio Salas-Whalen for a deep dive into GLP-1 medications (like Ozempic, Wegovy, and Mounjaro).




They cover everything you should be asking but probably haven’t heard:

  • The real reason GLP-1s exploded post-COVID
  • How these medications actually work (hint: it’s not just about appetite)
  • Why preserving muscle mass is non-negotiable—and how to do it
  • Hormones + GLP-1s: what the latest data says
  • Microdosing, maintenance, and the future of these meds
  • The emotional and social impact of weight loss no one talks about
  • And the biggest misconceptions about safety, cost, and who should prescribe them

Whether you're considering starting a GLP-1, currently using one, or just trying to untangle the noise, this conversation is packed with clarity, compassion, and actionable advice.




Chapters


00:00 Introduction to GLP-1 Medications
02:59 The Impact of COVID-19 on Obesity Awareness
05:54 Understanding GLP-1: History and Mechanism
09:10 The Role of GLP-1 in Weight Loss and Muscle Preservation
12:05 Nutrition and Muscle Mass: The Importance of Protein
15:06 The Gender Disparity in Hormone Treatments
17:57 Endocrinology and the Treatment of Sex Hormones
21:02 Personalization in GLP-1 Dosing
23:44 Understanding GLP-1 and Body Composition
27:12 Cost and Accessibility of GLP-1 Medications
28:38 Mechanism of Action of GLP-1
30:43 Impact of GLP-1 on Lifestyle and Relationships
33:57 Misconceptions and Safety of GLP-1 Medications
36:22 Education and Resources for Practitioners
37:25 Future of GLP-1 Drug Development
38:59 Metabolic Markers and Women's Health
41:25 Rocio's Upcoming Book and Patient Care Insights
46:06 Final Thoughts on GLP-1 and Patient Relationships
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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