GLP-1s, Muscle Loss, & Midlife Metabolism: What Women Really Need to Know

madman · Aug 7, 2025

In this episode of You Are Not Broken, Dr. Kelly Casperson sits down with endocrinologist and obesity medicine expert Dr. Rocio Salas-Whalen for a deep dive into GLP-1 medications (like Ozempic, Wegovy, and Mounjaro).

They cover everything you should be asking but probably haven’t heard:

The real reason GLP-1s exploded post-COVID
How these medications actually work (hint: it’s not just about appetite)
Why preserving muscle mass is non-negotiable—and how to do it
Hormones + GLP-1s: what the latest data says
Microdosing, maintenance, and the future of these meds
The emotional and social impact of weight loss no one talks about
And the biggest misconceptions about safety, cost, and who should prescribe them

Whether you're considering starting a GLP-1, currently using one, or just trying to untangle the noise, this conversation is packed with clarity, compassion, and actionable advice.

Chapters

00:00 Introduction to GLP-1 Medications
02:59 The Impact of COVID-19 on Obesity Awareness
05:54 Understanding GLP-1: History and Mechanism
09:10 The Role of GLP-1 in Weight Loss and Muscle Preservation
12:05 Nutrition and Muscle Mass: The Importance of Protein
15:06 The Gender Disparity in Hormone Treatments
17:57 Endocrinology and the Treatment of Sex Hormones
21:02 Personalization in GLP-1 Dosing
23:44 Understanding GLP-1 and Body Composition
27:12 Cost and Accessibility of GLP-1 Medications
28:38 Mechanism of Action of GLP-1
30:43 Impact of GLP-1 on Lifestyle and Relationships
33:57 Misconceptions and Safety of GLP-1 Medications
36:22 Education and Resources for Practitioners
37:25 Future of GLP-1 Drug Development
38:59 Metabolic Markers and Women's Health
41:25 Rocio's Upcoming Book and Patient Care Insights
46:06 Final Thoughts on GLP-1 and Patient Relationships

madman · Aug 7, 2025

Weightless

A board-certified endocrinologist shares her must-have guide to using GLP-1 medications, such as Ozempic, Wegovy, Mounjaro, and Zepbound, to reverse obesity and take charge of your health, with established strategies for maximizing your results. Order your copy of The GLP-1 Breakthrough now wherever

weightlessthebook.com

Amazon.com

madman · Aug 7, 2025

Thread 'No.1 Protein Scientist: Are you eating enough?'

Aug 7, 2025

Are you eating enough protein? This is probably a question you’ve asked yourself. With “high protein” labels on almost every type of food product you can imagine, it’s easy to get confused.

In this episode, Prof. Stuart Phillips explains how protein can keep us healthy as we age. He also outlines when we should eat protein, how much protein we really need, and provides simple, practical advice to help you achieve it. Stuart is a professor in the Kinesiology Department at McMaster University. He’s the author of more than 400 scientific papers, many...