From Joint Damage to Regeneration | Tomorrow's Cure

madman · Monday at 6:26 PM

What if repairing damaged cartilage could be done in a single procedure? Using your own cells and the healing signals they need to recover?

In this episode of Tomorrow's Cure, host Lindsey Seavert explores RECLAIM, an innovative regenerative medicine approach that combines a patient's own cartilage cells with donor medicinal signaling cells (MSCs) to help repair damaged joints. Joining the conversation are Dr. Daniel Saris and Dr. Mario Hevesi of Mayo Clinic, along with Dr. Christian Lattermann of Mass General Brigham.

Together, they discuss why cartilage injuries are so difficult to treat, how RECLAIM works, and why this breakthrough could reshape the future of orthopedic surgery, sports medicine, and joint preservation.

Timestamps

0:00 RECLAIM Advances Cartilage Repair
1:45 Why Damaged Cartilage Struggles to Heal
4:13 How RECLAIM Supports Joint Surgery
7:01 Recovery Time and Patient Experience
8:22 Treating the Entire Joint System
10:03 How RECLAIM Recycles Cartilage Cells
12:43 How Donor Cells Guide Healing
15:18 Expanding Treatment From Knees to Hips
18:05 New Uses Beyond Cartilage Repair
24:22 Patient Outcomes and Clinical Trial Results
27:28 AI, Precision Treatment and Future Access
32:09 Who May Be a RECLAIM Candidate
32:32 What Gives Researchers Hope
34:52 Aging, Cell Health and Joint Repair
38:20 Delaying Joint Replacement Through Preservation
39:25 Future Insights From RECLAIM Research
39:39 Closing Remarks and Podcast Credits

https://www.mayo.edu/research/departments-divisions/division-orthopedic-surgery/joint-restoration-reclaim

madman · Monday at 6:30 PM

Thread 'Cracking the Code of Cartilage Regeneration Failure'

Aug 11, 2023

Osteoarthritis (OA) is a widespread condition with significant impact, driven by cartilage injuries leading to OA progression. Effective cartilage regeneration methods are crucial, but current treatments lack reliability. This is due to a fundamental lack of understanding of cartilage regeneration failure. Research into these mechanisms is vital for patient treatment decisions and future therapy development. The review examines hypotheses behind cartilage regeneration failure and associated therapeutic strategies, offering insights into current and potential OA treatments.

Key...