Fierce female moles have male-like hormones and genitals

madman

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Moles live a tough life underground. As a result, they’ve evolved helpful adaptations, such as excavator-like claws. Female moles in particular have evolved an unusual strategy: high levels of the male hormone testosterone.

This is an evolutionary advantage. It produces stronger muscles for digging and foraging and aggression, to help mothers defend themselves and their young.

Most of the year, female moles look and behave like males. They have masculinized genitals, with no external vagina and an enlarged clitoris. But when mating season comes, testosterone levels drop and a vagina is formed; mating and birth follow.

How they accomplish this remained a mystery for a long time. But now, the complete sequencing of the mole genome has revealed the genetic tweaks underpinning this strange cycle in female moles, by which reproductive organs (gonads) develop and hormones are produced.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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