FDA Approves Pfizer Menopause Pill

Nelson Vergel

Founder, ExcelMale.com
The drug is a once-daily pill that combines the female hormone estrogen with the drug bazedoxifene. The drug represents an alternative to older menopause pills that combined estrogen with another hormone: progestin, which has been linked to increased risk of lung and breast cancer.


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Like all hormone therapies, Pfizer says the new drug should be used for "the shortest duration" possible to relieve symptoms, due to the potential health risks. The New York-based drugmaker said it expects to launch the drug in the first quarter of 2014.

The drugs label states that Duavee should not be used by women with a history of blood clots or certain cancers, including cancer of the uterus and breast.

For decades, doctors believed hormone pills helped prevent heart problems and were good for bones and minds. That changed in 2002, when a big federal study was stopped because women taking estrogen-progestin pills had higher rates of cardiovascular disease and cancer.

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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