Excess niacin causes blood vessel inflammation and cardiovascular disease

[sammmy]

They are finally realizing that anything promoting blood vessel inflammation, in this case excess niacin metabolites, can lead to cardiovascular disease. It's not the cholesterol.

Link Discovered Between Excess Niacin and Cardiovascular Disease

Cleveland Clinic researchers have identified a new pathway linked to excess niacin levels that contributes to cardiovascular disease independent of traditional risk factors. A newly discovered niacin-linked pathway contributing to cardiovascular disease raises the prospect of new therapeutic...

consultqd.clevelandclinic.org

 

[Vince]

At one time I did use niacin. I liked the flush that it gave me. It raised my HDL by 30% or more and lowered my triglycerides. According to the article it lowers LDL cholesterol which we all know is false. I no longer use niacin because it did cause issues with my labs.

 

[t_spacemonkey]

interesting. are they talking about niacinamide or nicotinic acid. NA never did anything to my lipids (i stopped caring about lipids completely long time ago other then TG)
but 'fortifying' foods in the usa with junk versions of vitamins is another story. tbh most of those foods are poison to begin with which I do not feed to my kids

 

[BigTex]

At one time I did use niacin. I liked the flush that it gave me. It raised my HDL by 30% or more and lowered my triglycerides. According to the article it lowers LDL cholesterol which we all know is false. I no longer use niacin because it did cause issues with my labs.

I had asked my former cardiologist about using niacin and he strongly suggest that I not use it due to what was said in the posting above. So I guess this has been suspected for a few years now.

 

[Vince]

Here's a thread I posted in 2016. A lot has changed since then.

Using Niacin to Improve Cardiovascular Health

By Roland Mills, MScHN, C-IN, HHP-BC Q: I recently had a cholesterol profile blood test and learned that I may be at risk of heart disease because my levels of beneficial HDL (high-density lipoprotein) are too low. I read that niacin could help increase my HDL, but my doctor said...

www.excelmale.com

 

[Vince]

 

[t_spacemonkey]

I am very cautious of any studies those days, especially when bullshit like this below comes out of the 'scientific community'. hard to know what to trust those days. in the below, they fed people some bullshit nestle protein drink with tons of sugar/soybean oil etc

 

[t_spacemonkey]

Increased Dietary Niacin Intake Improves Muscle Strength, Quality, and Glucose Homeostasis in Adults over 40 Years of Age

Age-related loss of skeletal muscle mass and strength begins at 40 years of age, and limited evidence suggests that niacin supplementation increases l…

www.sciencedirect.com

Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1

Niacin is a well established drug used to lower cholesterol and prevent cardiovascular disease events. However, niacin also causes cutaneous flushing side effects due to release of the proresolution mediator prostaglandin D[2] (PGD[2] ). Recent randomized ...

www.ncbi.nlm.nih.gov

of interest

 

[BigTex]

I am very cautious of any studies those days, especially when bullshit like this below comes out of the 'scientific community'. hard to know what to trust those days. in the below, they fed people some bullshit nestle protein drink with tons of sugar/soybean oil etc

View attachment 41655

AMEN! PUFA's, we already knew that food high in PUFA's cause issues. Not sure what protein supplements contain PUFA's.

 

[Systemlord]

They are finally realizing that anything promoting blood vessel inflammation, in this case excess niacin metabolites, can lead to cardiovascular disease. It's not the cholesterol.

Link Discovered Between Excess Niacin and Cardiovascular Disease

Cleveland Clinic researchers have identified a new pathway linked to excess niacin levels that contributes to cardiovascular disease independent of traditional risk factors. A newly discovered niacin-linked pathway contributing to cardiovascular disease raises the prospect of new therapeutic...

consultqd.clevelandclinic.org

It seems being proactive can sometimes come back to bite you!

 

[Mastodont]

Wondering about other forms, hyped nad precursors

 

[FunkOdyssey]

Wondering about other forms, hyped nad precursors

Same, they are all metabolized extensively into niacinamide. Not looking good IMO.

 

[Vince]

Office of Dietary Supplements - Niacin

Niacin (Vit B3) overview for health professionals. Research health effects, dosing, sources, deficiency symptoms, side effects, and interactions here.

ods.od.nih.gov

 

[BigTex]

Interestingly enough I posted something about niacin in 2022 and took a little heat from a couple of our members for even mentioning it. Maybe I should have kept this cardiologist?

EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS

Anyone notice impact on fasting and post-prandial glucose levels and a1c from taking high-dose ER niacin to manage lipids? I was on 1.5g per day and increased to 2g per day and now I'm noticing glucose levels about 10 points higher. Wondering if this will subside over time. I know some are...

www.excelmale.com

 

[t_spacemonkey]

i've been taking 500mg nicotinic acid for some time, but TBH did not experience any benefits at all (other then flushing). there is some data that it can boost NAD (cheeply). my lipids also did not change (not my goal to lower them). the study listed here is paid unfortunately, and all the niacin articles just repeat the same nonsense 'niacin harmful', and since this stuff is essentially in all foods, this study can be probably ignored.

 

[FunkOdyssey]

They say a picture is worth a thousand words:

 

[t_spacemonkey]

They say a picture is worth a thousand words:

View attachment 41680

so it appears that the problem is the garbage added to processed foods.

 

[FunkOdyssey]

so it appears that the problem is the garbage added to processed foods.

The problem is proposed to be any source of niacin/niacinamide/NAD in excess of our requirements, which would include fortified / enriched foods as well as any form of supplementation.

 

[BigTex]

Well you add that to the extra 2000 - 3000mg people take with the processed foods, that certainly seems like over kill. Especially when the RDA is 16mg/d. I eat a lot and only get around 55mg/d. That should be more than enough.

 

[Mastodont]

NAD intravenous drip :/