Estrogen management

robs2nd75

Member
At day 5 my T shot has worn off. My doc suggested SC 2x per week but this did not work for me. He has now prescribed Anastrozole 1-2 mg per week. He stated that I should take 1 mg on the day of my shot to decrease conversion and if needed halfway through the week. Does anyone have any thoughts/suggestions on this protocol?
 
Started TRT: TT 149 ref range 348-1197
FT 5.2 ref range 8.7-25.1

Most recent lab work (Day 3): TT 472 ref range 348-1197
estradiol 35 ref range 7.6-42.6

Previous lab work (Day 6):

[TD="class: xslValueColumn"]Estradiol, Sensitive[/TD]
[TD="class: xslValueColumn"]44 pg/mL[/TD]
[TD="class: xslValueColumn"]3-70 [/TD]

[TD="class: xslValueColumn"]Free Testosterone(Direct)[/TD]
[TD="class: xslValueColumn"]24.4 pg/mL[/TD]
[TD="class: xslValueColumn"]8.7-25.1 [/TD]
[TD="class: xslValueColumn"] [/TD]

[TD="class: xslValueColumn"]Testosterone, Serum[/TD]
[TD="class: xslValueColumn"]678 ng/dL[/TD]
[TD="class: xslValueColumn"]348-1197 [/TD]
 
The amount of Adex your doc is recommending will crash your E. You will not like this. Your E is a tad high to me but some people do better with a slightly higher level. It just depends on the person. LEF recommends a range of 20-30, but again, it's subjective. I may feel good at 20, you may not.

To me it appears you may be able to get by with DIM, Zinc & Copper as a first approach and avoid adex completely. It's always worth a shot. And your TT and FT look great! Lower that E a bit and they'll elevate more.
 
Kelly, my last lab was 472 w/ estradiol at 35. This was day 3 on 75mg e3.5d SC. He switched me back to IM once weekly and increased to 200mg. I know estrogen is going to elevate w/ the new protocol. What do you think of .25 on day of shot to partially block conversion?
 
Ideally, arimidex should be taken 24 hours after injection. But I agree with Kelly, seems like super high doses there. DIM/zinc/Copper seems to work great for me.
 
Austin beat me to it and he's correct. 24hrs after injection and dose as low as possible (maybe .25) if you go the adex route. Check labs in a month.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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