When my estradiol level plummeted a few months ago due to my excessive Anastrazole doses (.25mg nightly), y'all's opinion was that it was probably the cause of my severe myligia in my right shoulder. Since then I cut back to .25mg weekly, then as of 25 Dec I stopped Anastrazole completely. My shoulder pain has virtually disappeared. Thank you so much guys (Ero, Coastwatcher, Israel). I've scheduled a ultra sensitive estradiol assay for 26 Jan expecting my estradiol level to have climbed. My doctor is pretty much letting me call the shots as she's inexperienced with severely depleted estradiol issues. Upon receiving the lab results, if needed I'll consider a compounded very small dose daily AI to bring it to a suitable level (20-25), then fine tune by the known indicators (erections, morning/nocturnal wood, mood swings, etc.) Thanks again, y'all may have saved my life if my estradiol had zero'd out.