Estradiol E2 Testing in Men: Comparison Between Regular and Sensitive E2 Assays

I've had the same weird result.
Standard E2 ran by Labcorp came back at 67.
E2 LC/MS ran by BioReference was 16.
I was experience joint pain and dry skin, so I guess Labcorp was wrong. Dr. Rotman also told me he's not a big fan of Labcorp.

I didn't test C-RP, so I don't if that's the reason.
 
Wondering, I am struggling with ED that was brought on after my first month on TRT, the only thing I can come up with is to get my E2 higher, I am stopping the AI next month and will see how I do with higher E2.

Nelson, I appreciate the info on the CRP, I will study it.
If you can lower your dose of Testosterone so that you don't need an A.I when i first started i tried using an A.I but was oversensitive to it...when i got dialled in it was ok but off it I feel much better especially if you add in a little HCG as well but note again hcg effects everyone differently i only do about 150-200IU 2x week as 250-500 will raise my Estrogen too high.

Pretty much all trial and error and go by how you feel rather then aiming for a certain number!

I have also found the non sensitive test to be pretty accurate, They don't have the sensitive test in the country i live in.
 
I’m confused..I thought having a low CRP was a good thing? At least that’s what my doctor tells me..he’s always checking my CRP on every blood test..Any clarifications would be appreciate..
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
6
Guests online
233
Total visitors
239

Latest posts

Back
Top