Estradiol deviation for improvement or symptoms

[Zooka15]

Just was curious, Some say the ideal E2 range is 20-30, 20-40, or as closet to 20. My question is say you have a E2 of 32 will you notice a improvement in mood, EQ, libido and so on if you get that number to 22. Same goes for the other direction starting E2 is 22 and you climb to 32 will you notice a decline in mood, EQ, and so on.

 

[CoastWatcher]

Just was curious, Some say the ideal E2 range is 20-30, 20-40, or as closet to 20. My question is say you have a E2 of 32 will you notice a improvement in mood, EQ, libido and so on if you get that number to 22. Same goes for the other direction starting E2 is 22 and you climb to 32 will you notice a decline in mood, EQ, and so on.

You get nowhere chasing numbers. I do just fine if my estradiol is somewhere between 25 and 38/sensitive test. Higher than that, some problems. Lower than that, some problems. I have never taken an AI. The range is there to guide you and your doctor, not to lock you into a rigid grid. Each of us is different and it is impossible to say how a patient will feel with an estradiol of X as opposed to Y. Too low - you won't feel good. Too high - you won't feel good. And remember, estradiol is a critically important hormone for men; it's not a waste product to be suppressed at all costs.

 

[ERO]

It is very different for everybody and there are many other variables to take into consideration. A big one is the Testosterone to Estrogen ratio. For example, an E2 of 32 means nothing much without also knowing the Total and Free T levels. Said another way, a guy at 400 total T and E2 of 32 is not going to feel the same as a guy with a 900 Total T and an E2 of 32.

 

[Nelson Vergel]

I think the biggest scam in the field today is telling patients that estradiol is tied to mood and that small changes matter. Such waste of energy and time! Not one study has shown negative effects on mood with estradiol under 50 pg/mL or above.

Testosterone Needs Estrogen's Help to Inhibit Depression

I invite anyone to tell me that anastrozole improved their mood.

 

[Vince]

I've never taken an AI, so far I have not felt any effects from high or low E2.

 

[Jon H]

Nelson - If my estradiol gets much above 30 then I tend to get moody and short tempered with my family. If my estradiol gets under 20 then I tend to get emotionless/clinical with how I treat those around me, and lose both emotional highs and lows. I agree that small changes don't matter a lot, but the definition of a "small change" is different from person to person. For a lot of guys, a swing from 29 to 40 might not be a lot. For me a swing from 29 to 35 is enormous.

So for me the answer is "Yes, anastrozole has a potentially very big impact on my mood; both positively and negatively". Studies or not, this is definitely the case for me and my mood is almost a barometer of what my E2 will be when I go to get blood tests.