Estradiol - Comparing ECLIA vs LC/MS/MS results

[S1W]

I recently had lab work and got the ECLIA E2 test. I know my results for both tests are "high", however I'm curious as to how any comparison might be made to previous tests that used LC/MS/MS.

Previous E2 labs using LC/MS/MS:

47.2 pg/ml (8.0-35.0)

Current E2 labs using ECLIA:

69.2 pg/ml (7.6-42.6)

Both are measured in pg/ml, however they use different ranges. If any direct correlation cannot be made, is it safe to say that my E2 went up?

 

[Cataceous]

It's too little data to say anything with certainty. If you assume you're statistically average then the ECLIA test is presumed to be only a few percent higher than the LC/MS/MS test. This would imply your estradiol has gone up. However, if you happen to have higher levels of C-reactive protein then that could be inflating the ECLIA result. On the other side, the LC/MS/MS tests are occasionally wildly inaccurate, far more often than the ECLIA tests, which are at least very repeatable.

 

[Gman86]

These are all the times I’ve had both tested at the same time. As u can see, there’s no real way to answer your question. Sometimes the sens E2 is higher than the standard, sometimes lower. Ime, if u know ur E2 isn’t very low, I would honestly just go with and trust the standard E2 test. It seems a little more reliable, imo. The sens version is at higher risk of lab error.


8-15-17
E2 Sensitive - 8
E2 NOT Sensitive - 13
E2 Free - 0.28 (0.2-1.5)
SHBG 51 (10-50)
Albumin - 4.6g/dL (3.6-5.1)

12-13-17
E2 Sensitive - 9
E2 NOT Sensitive - 13
E2 Free - 0.28 (0.2-1.5)
SHBG 36 (10-50)
Albumin - 4.4g/dL (3.6-5.1)

7-9-18
E2 Sensitive - 46
E2 NOT Sensitive - 27
E2 Free - 0.58 (0.2-1.5)
SHBG 47 (10-50)
Albumin - 4.6g/dL (3.6-5.1)

8-24-18
E2 Sensitive - 57
E2 NOT Sensitive - 56
E2 Free - 1.35 (0.2-1.5)
SHBG 41 (10-50)
Albumin - 4.3g/dL (3.6-5.1)

10-23-18
E2 Sensitive - 58
E2 NOT Sensitive - 68
E2 Free - 1.48 (0.2-1.5)
SHBG 44 (10-50)
Albumin - 4.6g/dL (3.6-5.1)

12-6-18
E2 Sensitive - 10
E2 NOT Sensitive - 15
E2 Free - 0.33 (0.2-1.5)
SHBG 45 (10-50)
Albumin - 4.7g/dL (3.6-5.1)

1-25-19
E2 Sensitive - 29
E2 NOT Sensitive - 27
E2 Free - 0.67 (0.2-1.5)
SHBG 40 (10-50)
Albumin - 4.5g/dL (3.6-5.1)

2-20-19
E2 Sensitive - 28
E2 NOT Sensitive - 32
E2 Free - 0.76 (0.2-1.5)
SHBG 44 (10-50)
Albumin - 4.6 (3.6-5.1)

4-30-19
E2 Sensitive - 72
E2 NOT Sensitive - 49 (I think this is correct, not the sens. E2)
E2 Free - 1.02 (0.2-1.5)
SHBG 63 (10-50)
Albumin - 4.3 (3.6-5.1)

7–23-19
SHBG 39 (10-50)
E2 Sensitive - 45
E2 NOT Sensitive - 41
E2 Free - 0.94 (0.2-1.5)
Albumin - 4.7 (3.6-5.1)


8-28-19
SHBG 40 (10-50)
E2 Sensitive - 78
E2 NOT Sensitive - 71
E2 Free - 1.81 (0.2-1.5)
Albumin - 4.4 (3.6-5.1)

11-2-19
SHBG 40 (10-50)
E2 Sensitive - 78
E2 NOT Sensitive - 71
E2 Free - 1.81 (0.2-1.5)
Albumin - 4.4 (3.6-5.1)


11-30-19
SHBG - 33 (10-50)
E2 Sensitive - 79
E2 NOT Sensitive - 88
E2 Free - 2.49 (0.2-1.5)