Effects of GLP-1 Receptor Agonists on Male Reproductive Hormones, Semen Parameters and Metabolic Outcomes

[madman]

Takeaway Messages

 

[madman]

 

[madman]

Research Question

Methodology

Study Selection & Characteristics

 

[madman]

Hormonal Outcomes: Total Testosterone

Hormonal: Free Testosterone & SHBG

Hormonal Outcomes - Gonadotropins (LH & FSH)

Semen Parameters

 

[madman]

Metabolic Outcomes

 

[madman]

Limitations & Recommendations

 

[madman]

Takeaway Messages

 

[madman]

Thread 'Can GLP‑1 Drugs Like Semaglutide Boost Testosterone? New Review Reveals Surprising Results'

Oct 28, 2025

* Among the human studies, 9 evaluated testosterone levels (total and/or free), 6 reported on gonadotropins (LH, FSH), and 5 assessed clinical hypogonadal symptoms such as libido and erectile function. In total, 7 human studies demonstrated a statistically significant increase in testosterone levels following GLP-1 agonist treatment, with stronger effects observed in men with obesity, T2DM, and baseline low testosterone. Two human studies showed no change or mild reductions in testosterone among eugonadal men without metabolic disease.


* GLP-1 receptor...

• madman
• hypogonadism; obesity; t2dm; glp-1
• Replies: 2
• Forum: General Peptide Use & Information

 

[madman]

Thread 'Beyond Blood Sugar: GLP-1 Receptor Agonists as a Multifaceted Therapy for Testosterone, Erectile Function, and Metabolic Outcomes in Men with Obesity'

May 9, 2025

* Given emerging data on sarcopenia and GLP-1 RAs, future studies should investigate the potential role of combined GLP-1 and testosterone therapies to optimize outcomes in body composition, metabolic control, and sexual health.





Table 1. Impact of GLP-1 Receptor Agonist Therapy on Testosterone Levels, Sexual Healthm and Metabolic parameters in Men with Obesity or Type 2 Diabetes: Summary statistics

PRELIMINARY ASSESSMENT OF GLP-1 RECEPTOR AGONISTSON TESTOSTERONE LEVELS, ERECTILE FUNCTION, ANDMETABOLIC OUTCOMES IN MEN WITH OBESITY OR TYPE...

• madman
• glp-1; obesity; sarcopenia; t; ed
• Replies: 2
• Forum: Weight Loss Options