ED Medications and Risk of Malignant Melanoma

[CoastWatcher]

Previous research purported to show a link between malignant melanoma and the use of PDE5 inhibitors (Cialis, Viagra, etc.). Recently, The JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION published a study that showed a small, but "statistically significant increased risk of malignant melanoma" in men taking PDE5 inhibitors (Cialis, Viagra, etc.). However, the "most pronounced increase in risk was observed in men who had filled a single prescription (OR, 1.32 [95% CI, 1.10-1.59]; exposure rate, 4% for cases vs 3% for controls), but was not significant among men with multiple filled prescriptions." Regular users of PDE5 drugs (in this study) were not at increased risk. Somewhat puzzling, is the association causal? It is, however, good news for those using these drugs regularly.



http://jama.jamanetwork.com/article.aspx?articleid=2338254

 

[Vince]

I've seen the results of melanoma, it's a terrible cancer. A number of genes are being investigated for their role in melanoma, including inherited genes. ( I quess all genes are hereditary )

 

[Nelson Vergel]

Taking PDE5 inhibitors for erectile dysfunction unlikely to increase risk of skin cancer
Previous studies on a possible increase in melanoma risk in men prescribed one of the drugs have come to conflicting conclusions, and consequently Anthony Matthews and colleagues carried out a large study in UK men, using anonymized data from the Clinical Research Practice Datalink.
This study involved a comparison of 145,104 men prescribed a PDE5 inhibitor with 560,933 controls. The researchers observed a slight increase in risk of cutaneous melanoma (adjusted hazard ratio 1.14, 95% CI 1.01-1.29, p=0.04). However, similar increases in risk of basal cell carcinoma and solar keratosis, which are known to be related to sun exposure, were observed, while there was no increase in risk of colorectal carcinoma, which is unrelated to sun exposure.
In addition, the group of men prescribed a PDE5 inhibitor experienced a higher risk of solar keratosis even in the period before receiving their first prescription, suggesting that they had higher rates of sun exposure on average than the control group.
Krishnan Bhaskaran, the study's senior author, said "All of our observations pointed towards the small apparent increase in risk of melanoma in men prescribed PDE5 inhibitors being explained by greater sun exposure, rather than a side-effect of the drugs themselves."

http://www.medicalnewstoday.com/releases/311001.php

 

[TestAdvocate]

Thanks for sharing this info guys. I literally just took my very first dose of Cialis yesterday (10/mg), then a single Viagra pill last night before sex with my wife. What a help it was. The last 6 months have been very inconsistent and unreliable erections..........last night was awesome with my wife. I couldn't believe the difference it made. Very thankful for the drugs indeed......and the Cialis is a very nice maintenance drug to control prostate growth. Glad the cancer scare seems to be not totally warranted.