Excessive androgen exposure and risk of malignancies: A cohort study.

[Wilson7]

Abstract Background: A link between androgen use and the risk of cancers, especially prostate and breast cancer, has been suggested. The knowledge about a possible association is limited.

Objective: The study aimed to investigate cancer incidence rates, particularly those related to prostate and breast cancer, in male androgen users and compare them to a control group.

Methods: We included male androgen users identified through a nationwide antidoping testing program in Danish fitness centers from 2006 to 2018. We paired each case with 50 male controls of the same age, selected randomly. The cohort was followedfrombaselineanduntil2023.The outcome was the incidence of prostate cancer, breast cancer, or any cancer excluding non-melanoma skin cancer.

Results: The study included 1,189 androgen users and 59,450 controls, with a mean age of 27 years at enrolment. During the follow-up period with a mean length of 11 years, 13 androgen users, and 612 controls were diagnosed with cancer. This resulted in an incidence rate ratio of 1.05(95%CI:0.55–1.81). None of the androgen users were diagnosed with prostate or breast cancer.

Discussion and conclusion: Male androgen users did not face an increased short-term risk of cancer, neither overall nor related to prostate or breast cancer. Our study indicates that the absolute risk of malignancies in androgen users is comparable to that in the back ground population. However, we cannot exclude androgens as a cancer risk factor due to the limited sample size,relatively short follow-up period, and subject age.

 

[Seagal]

Gynecomastia is prevalent among bodybuilders probably due to excessive amount of estradiol
which arises from the metabolism oftestosterone.

Transgender women, who were assigned male at birth but identify as female treated with estrogen have a 46 times higher risk of developing breast cancer compared to estrogen unexposed cis-men.

I really do Not want to start yet another estradiol discussion.

Check out Figure 1:
The mortality following the cancer diagnoses among AAS users and controls

 

[DorianGray]

{"Transgender women, who were assigned male at birth but identify as female treated with estrogen have a 46 times higher risk of developing breast cancer compared to estrogen unexposed cis-men."}

It would be interesting to see a risk profile compared to women overall.

 

[FunkOdyssey]

{"Transgender women, who were assigned male at birth but identify as female treated with estrogen have a 46 times higher risk of developing breast cancer compared to estrogen unexposed cis-men."}

It would be interesting to see a risk profile compared to women overall.

 

[Wilson7]

You are forgetting, MTF have their T levels crushed along with anti-androgens. That is now a very high E2 to T and DHT ratio. If you look at Glaser et al studies, T is neutral to protect against BCa in women, and decades ago they would give Test P to women for metastatic BCa to slow the progression. That is also in large part why androgen analogues were developed as AIs were not available.We wanted to tilt the ratios in favor of androgens vs E2 wo the androgenic sides. Don't assume that a higher E2 in the presence of high T increases risk of male BCa and in the above study, there was a 16% incidence of gyno in the steroid users, but no reports of male breast cancer.

 

[RobRoy]

Gynecomastia is prevalent among bodybuilders probably due to excessive amount of estradiol
which arises from the metabolism oftestosterone.

Transgender women, who were assigned male at birth but identify as female treated with estrogen have a 46 times higher risk of developing breast cancer compared to estrogen unexposed cis-men.

I really do Not want to start yet another estradiol discussion.

Check out Figure 1:
The mortality following the cancer diagnoses among AAS users and controls

Gynecomastia is multifactoral and not related to just estradiol. If you don't want to have another estradiol comment then quit making inaccurate comments about estradiol.

Gynecomastia: Etiology, Diagnosis, and Treatment - Endotext - NCBI Bookshelf

 

[Seagal]

Gynecomastia is multifactoral and not related to just estradiol. If you don't want to have another estradiol comment then quit making inaccurate comments about estradiol.

Gynecomastia: Etiology, Diagnosis, and Treatment - Endotext - NCBI Bookshelf

You are half right. This was a citation of the paper, which I failed to mark as such. That's a discussion about the paper... I thought it would be.
I see now I should be more careful, it's not a journal club.
Anyway, I appreciate your contributions to this forum.