Dosage for women's testosterone ?

[Nelson Vergel]

Here is a good summary : Practical Clinical Summary on Testosterone Therapy in Women - Excel Male Health Forum

 

[Guided_by_Voices]

Hi GBV. Hope all is well. And no, we haven't tried any of those yet. Last 2 years we have been trying to raise her e2 using gels, sprays, patches, pills which all failed tremendously. Libido is not my main task, raising her chronically nuked e2 is and what will come with it will be a bonus. Shes 50 and been very low e2 probably half her life which is fucking brutal and detrimental. We have everything covered by the NHS and basically get all the moving parts for free yet nothing worked and we are frustrated af. Worn out and tired from all this not even talking about her terrible e2 symptoms. Shes sad that these 2 years we didn't manage to move the needle into right direction just know now that all this crap we tried did pretty much nothing for her e2. T didn't bring anything else just some energy no matter what dose 5-25mg/week. She has high natural total t but nuked free t and high 150s shbg fwiw. So yeah seems the only way to sort this is to buy injectable e2 and get the ball rolling asap. Your mentioned stuff is also very interesting but after 2 years non-stop experimenting, logging, thinking and shit shes burned out but still willing to explore further things down the line.

I certainly hope you find something that works. I remember hearing years ago that DHEA in women almost entirely converts to some form of estrogen, so that's why I mentioned it.

 

[t_spacemonkey]

Hi GBV. Hope all is well. And no, we haven't tried any of those yet. Last 2 years we have been trying to raise her e2 using gels, sprays, patches, pills which all failed tremendously. Libido is not my main task, raising her chronically nuked e2 is and what will come with it will be a bonus. Shes 50 and been very low e2 probably half her life which is fucking brutal and detrimental. We have everything covered by the NHS and basically get all the moving parts for free yet nothing worked and we are frustrated af. Worn out and tired from all this not even talking about her terrible e2 symptoms. Shes sad that these 2 years we didn't manage to move the needle into right direction just know now that all this crap we tried did pretty much nothing for her e2. T didn't bring anything else just some energy no matter what dose 5-25mg/week. She has high natural total t but nuked free t and high 150s shbg fwiw. So yeah seems the only way to sort this is to buy injectable e2 and get the ball rolling asap. Your mentioned stuff is also very interesting but after 2 years non-stop experimenting, logging, thinking and shit shes burned out but still willing to explore further things down the line.

she might be very well HRT optimized and her libido is beyond the reach of pure hormones. on the physical side there is things like melatonan 2 which ramped my wife's libido, especially when combined with sunshine (or UV light). dietary changes etc worth exploring. but in my exp libido is a mix of hormones and mental states. without the hormones nothing works ofc, and I hope something will move the needle for you, but there is limits

 

[Vince]

I certainly hope you find something that works. I remember hearing years ago that DHEA in women almost entirely converts to some form of estrogen, so that's why I mentioned it.

If I remember right. Dhea increases testosterone in women and estrogen in men.

In post menopause women, it also raises estrogen.

 

[Belekas]

she might be very well HRT optimized and her libido is beyond the reach of pure hormones. on the physical side there is things like melatonan 2 which ramped my wife's libido, especially when combined with sunshine (or UV light). dietary changes etc worth exploring. but in my exp libido is a mix of hormones and mental states. without the hormones nothing works ofc, and I hope something will move the needle for you, but there is limits

She is chronically e2 deficient and nothing raises that. That is our main priority. She has all other boxes ticked no worries about that. As I said in post we need to raise her e2 and asap because all the detremental effects of chronically nuked e2. We fix her e2 and then we will see what happens. I've been in this game a long time and I know that libido is multifactorial and that is not what is our priority to fix for now. Step by step but without raising her nuked e2 nothing will work.

 

[Belekas]

I certainly hope you find something that works. I remember hearing years ago that DHEA in women almost entirely converts to some form of estrogen, so that's why I mentioned it.

What do you think should be a reasonable dose for her? Not sure if thats worth exploring as her estrogen is deep in the gutter and shes struggling. I know how bad this is trust me plus we need to raise her estrogen asap because she is in a high risk group as all her family passed away from cancer including mother, father and her sister as well. And since 2 years we've been experimenting without much success and now just Testogel for her till we get injectable estrogen. It's really a tough situation but im just happy shes in top shape and form, lean, working out, active and eats like a queen with all my knowledge and help.

 

[Belekas]

If I remember right. Dhea increases testosterone in women and estrogen in men.

In post menopause women, it also raises estrogen.

have anything to read about it? Her estrogen is nuked and neither patch, gel, spray or pill helps. Its crazy but it is what it is.

 

[Guided_by_Voices]

What do you think should be a reasonable dose for her? Not sure if thats worth exploring as her estrogen is in the gutter and shes struggling. I know how bad this is trust me plus we need to raise her estrogen asap because she is in a high risk group as all her family passed away from cancer including mother, father and her sister as well. And since 2 years we've been experimenting without much success and now just Testogel for her till we get injectable estrogen. It's really a tough situation but im just happy shes in top shape and form, lean, working out, active and eats like a queen with all my knowledge and help.

Both DHEA and pregnenolone are upstream of e2 in the hormonal cascade, so perhaps they will help if supplementation is not working due to some sort to of absorption issue. A pure guess on dosage would be 10-25mg to start with and then adjust from there based on results. Also, if something is causing the enzyme which breaks e2 down to overexpress (cytochrome p450) then that is another pathway to explore, but I know nothing about that.

 

[Belekas]

Both DHEA and pregnenolone are upstream of e2 in the hormonal cascade, so perhaps they will help if supplementation is not working due to some sort to of absorption issue. A pure guess on dosage would be 10-25mg to start with and then adjust from there based on results. Also, if something is causing the enzyme which breaks e2 down to overexpress (cytochrome p450) then that is another pathway to explore, but I know nothing about that.

Fair enough mate and appreciate the knowledge and info every time. So we will try getting injectable e2 and already asked for Anavar. Will see if we can get some DHEA as well and prepare a plan on how we will attack. Shes now a week or so back on Testogel already feeling better in her head, more calm and bit more energy. So all that is good news but still early and still without any real e2 support which is really terrible so hopefully we will figure it out sooner then later. I'll explore what you said about cytohrome p450 when I have time. Thank you.

 

[Vince]

have anything to read about it? Her estrogen is nuked and neither patch, gel, spray or pill helps. Its crazy but it is what it is.

Actually in the study. Did not look good for improved libido.

Should Dehydroepiandrosterone Be Administered to Women? - PMC

Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in ...

pmc.ncbi.nlm.nih.gov

 

[Guided_by_Voices]

Actually in the study. Did not look good for improved libido.

Should Dehydroepiandrosterone Be Administered to Women? - PMC

Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in ...

pmc.ncbi.nlm.nih.gov

Note that the study looked at "normal" women. What applies on average to "normal' people may not apply to special exception cases, which is what Belekas' SO's situation sounds like. The bottom line is that as is almost always the case, there is no substitute for experimentation once the obvious and usual things have been tried. We don't know what is going on in the body with great precision and/or in individual extreme cases. Also, the study said that in some cases the women had "estrogenic" side effects, which for the case at hand would likely be a good thing.

 

[Vince]

Note that the study looked at "normal" women. What applies on average to "normal' people may not apply to special exception cases, which is what Belekas' SO's situation sounds like. The bottom line is that as is almost always the case, there is no substitute for experimentation once the obvious and usual things have been tried. We don't know what is going on in the body with great precision and/or in individual extreme cases. Also, the study said that in some cases the women had "estrogenic" side effects, which for the case at hand would likely be a good thing.

I thought the study said long-term DHEA therapy in postmenopausal women. Maybe I misread.