Does yohimbine's fat burning effects work with continued use?

rawhide

New Member
I've read conflicting reports regarding yombine's fat burning effects. Apparently it's noradrenaline stimulating effects wear off after 14 days continued use (ref1). Most guides recommend cycling it, but I have read other reports of extended use of more than a year with good effects. I always take it fasted before working out. I've noticed the side effects have become almost non-existent even at very high doses like 20mg 2x a day. On the contrary it give me a very positive mood lifting effect which I would enjoy even without the fat burning effects. I am concerned about becoming dependent on it.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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