Does DIM really works to lower estrogen?
- Thread starter Roccc
- Start date
Vince Carter
Banned
I beleive it works more towards mitigating some symptoms of Estrogen or eliminating some bad estrogens (whatever that is) but as far as lowering Estrogen, I don't think so. I don't use it.
Vince Carter
Banned
ya that's it that's what I was thinking, thanks Harry
Nelson Vergel
Founder, ExcelMale.com
I could not find one single study that looked at using DIM to modulate estrogen in men. Here is one for women:
3,3'-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study
Rajoria, Shilpi, et al. "3,3'-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study." Thyroid, vol. 21, no. 3, 2011, p. 299+. Health Reference Center Academic
Abstract:
Background: The incidence of thyroid cancer is four to five times higher in women than in men, suggesting a role for estrogen ([E.sub.2]) in the pathogenesis of thyroid proliferative disease (TPD) that comprises cancer and goiter. The objective of this study was to investigate the antiestrogenic activity of 3,3'-diindolylmethane (DIM), a bioactive compound derived from cruciferous vegetables, in patients with TPD.
Methods: In this limited phase I clinical trial study, patients found to have TPD were administered 300 mg of DIM per day for 14 days. Patients subsequently underwent a total or partial thyroidectomy, and tissue, urine, and serum samples were collected. Pre- and post-DIM serum and urine samples were analyzed for DIM levels as well as estrogen metabolites. DIM levels were also determined in thyroid tissue samples.
Results: DIM was detectable in thyroid tissue, serum, and urine of patients after 14 days of supplementation. Urine analyses revealed that DIM modulated estrogen metabolism in patients with TPD. There was an increase in the ratio of 2-hydroxyestrones (C-2) to 16[alpha]-hydroxyestrone (C-16), consistent with antiestrogenic activity that results in more of C-2 product compared with C-16.
Conclusion: Our data suggest that DIM enhances estrogen metabolism in TPD patients and can potentially serve as an antiestrogenic dietary supplement to help reduce the risk of developing TPD. The fact that DIM is detected in thyroid tissue implicates that it can manifest its antiestrogenic activity in situ to modulate TPD.
3,3'-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study
Rajoria, Shilpi, et al. "3,3'-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study." Thyroid, vol. 21, no. 3, 2011, p. 299+. Health Reference Center Academic
Abstract:
Background: The incidence of thyroid cancer is four to five times higher in women than in men, suggesting a role for estrogen ([E.sub.2]) in the pathogenesis of thyroid proliferative disease (TPD) that comprises cancer and goiter. The objective of this study was to investigate the antiestrogenic activity of 3,3'-diindolylmethane (DIM), a bioactive compound derived from cruciferous vegetables, in patients with TPD.
Methods: In this limited phase I clinical trial study, patients found to have TPD were administered 300 mg of DIM per day for 14 days. Patients subsequently underwent a total or partial thyroidectomy, and tissue, urine, and serum samples were collected. Pre- and post-DIM serum and urine samples were analyzed for DIM levels as well as estrogen metabolites. DIM levels were also determined in thyroid tissue samples.
Results: DIM was detectable in thyroid tissue, serum, and urine of patients after 14 days of supplementation. Urine analyses revealed that DIM modulated estrogen metabolism in patients with TPD. There was an increase in the ratio of 2-hydroxyestrones (C-2) to 16[alpha]-hydroxyestrone (C-16), consistent with antiestrogenic activity that results in more of C-2 product compared with C-16.
Conclusion: Our data suggest that DIM enhances estrogen metabolism in TPD patients and can potentially serve as an antiestrogenic dietary supplement to help reduce the risk of developing TPD. The fact that DIM is detected in thyroid tissue implicates that it can manifest its antiestrogenic activity in situ to modulate TPD.
Nelson Vergel
Founder, ExcelMale.com
Effect on PSA is good. But I am not sure I want anything to affect my androgen receptors (AR).
Am J Transl Res. 2016; 8(1): 166–176.
Published online 2016 Jan 15.
PRODUCT USED: BioResponse[R] DIM tablets (Bioresponse, Boulder, CO) (300 mg/day) for 14 days.
Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients
Clara Hwang,1 Seema Sethi,2 Lance K Heilbrun,3 Nilesh S Gupta,4 Dhananjay A Chitale,4 Wael A Sakr,2 Mani Menon,5 James O Peabody,5 Daryn W Smith,3 Fazlul H Sarkar,2,3 and Elisabeth I Heath3
Abstract
Consumption of cruciferous vegetables is associated with a decreased risk of developing prostate cancer. Antineoplastic effects of cruciferous vegetables are attributable to bioactive indoles, most prominently, 3, 3'-diindolylmethane (DIM). In addition to effects on proliferation and apoptosis, DIM acts as an antiandrogen in prostate cancer cell lines. This study characterized the effects of prostatic DIM on the androgen receptor (AR) in patients with prostate cancer. Men with localized prostate cancer were treated with a specially formulated DIM capsule designed for enhanced bioavailability (BR-DIM) at a dose of 225 mg orally twice daily for a minimum of 14 days. DIM levels and AR activity were assessed at the time of prostatectomy. Out of 28 evaluable patients, 26 (93%) had detectable prostatic DIM levels, with a mean concentration of 14.2 ng/gm. The mean DIM plasma level on BR-DIM therapy was 9.0 ng/mL; levels were undetectable at baseline and in follow-up samples. AR localization in the prostate was assessed with immunohistochemistry. After BR-DIM therapy, 96% of patients exhibited exclusion of the AR from the cell nucleus. In contrast, in prostate biopsy samples obtained prior to BR-DIM therapy, no patient exhibited AR nuclear exclusion. Declines in PSA were observed in a majority of patients (71%). Compliance was excellent and toxicity was minimal. In summary, BR-DIM treatment resulted in reliable prostatic DIM levels and anti-androgenic biologic effects at well tolerated doses. These results support further investigation of BR-DIM as a chemopreventive and therapeutic agent in prostate cancer.
Am J Transl Res. 2016; 8(1): 166–176.
Published online 2016 Jan 15.
PRODUCT USED: BioResponse[R] DIM tablets (Bioresponse, Boulder, CO) (300 mg/day) for 14 days.
Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients
Clara Hwang,1 Seema Sethi,2 Lance K Heilbrun,3 Nilesh S Gupta,4 Dhananjay A Chitale,4 Wael A Sakr,2 Mani Menon,5 James O Peabody,5 Daryn W Smith,3 Fazlul H Sarkar,2,3 and Elisabeth I Heath3
Abstract
Consumption of cruciferous vegetables is associated with a decreased risk of developing prostate cancer. Antineoplastic effects of cruciferous vegetables are attributable to bioactive indoles, most prominently, 3, 3'-diindolylmethane (DIM). In addition to effects on proliferation and apoptosis, DIM acts as an antiandrogen in prostate cancer cell lines. This study characterized the effects of prostatic DIM on the androgen receptor (AR) in patients with prostate cancer. Men with localized prostate cancer were treated with a specially formulated DIM capsule designed for enhanced bioavailability (BR-DIM) at a dose of 225 mg orally twice daily for a minimum of 14 days. DIM levels and AR activity were assessed at the time of prostatectomy. Out of 28 evaluable patients, 26 (93%) had detectable prostatic DIM levels, with a mean concentration of 14.2 ng/gm. The mean DIM plasma level on BR-DIM therapy was 9.0 ng/mL; levels were undetectable at baseline and in follow-up samples. AR localization in the prostate was assessed with immunohistochemistry. After BR-DIM therapy, 96% of patients exhibited exclusion of the AR from the cell nucleus. In contrast, in prostate biopsy samples obtained prior to BR-DIM therapy, no patient exhibited AR nuclear exclusion. Declines in PSA were observed in a majority of patients (71%). Compliance was excellent and toxicity was minimal. In summary, BR-DIM treatment resulted in reliable prostatic DIM levels and anti-androgenic biologic effects at well tolerated doses. These results support further investigation of BR-DIM as a chemopreventive and therapeutic agent in prostate cancer.
Nelson Vergel
Founder, ExcelMale.com
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