Do receptors get "clogged" - Androgen Receptor Regulation

If we are talking about the use of bio identical hormones to bring serum levels back to youthful levels I don't, and have never read, of receptor tolerance.

Think about if for a minute, when you were in your early 20's, and your androgen serum levels were screaming at peak levels. did you have any receptor tolerance?

Answer: No.

So, if we bring a man who is age related androgen deficient and raise his levels back to that of a healthy youthful male of 25 why would we believe there would be receptor tolerance?

Now for the aas crowd; just take a look at Jay Cutler or Phil Heath and tell me there's receptor tolerance LOL ;)

Just my $0.02.

gd

PS Good to see you here Marco!
 
If we are talking about the use of bio identical hormones to bring serum levels back to youthful levels I don't, and have never read, of receptor tolerance.

Think about if for a minute, when you were in your early 20's, and your androgen serum levels were screaming at peak levels. did you have any receptor tolerance?

Answer: No.

So, if we bring a man who is age related androgen deficient and raise his levels back to that of a healthy youthful male of 25 why would we believe there would be receptor tolerance?

Now for the aas crowd; just take a look at Jay Cutler or Phil Heath and tell me there's receptor tolerance LOL ;)

Just my $0.02.

gd

PS Good to see you here Marco!

Speaking of Jay and Phil, I will be seeing them at this year's Mr. O Expo here in Vegas starting tomorrow! We always joke about those guys towing a portable AAS pharmacy behind their rides. I'm going to try and get there early to see Carl Lanore of Super Human Radio.

You think Jay has a chance against Phil this year?
 
Speaking of Jay and Phil, I will be seeing them at this year's Mr. O Expo here in Vegas starting tomorrow! We always joke about those guys towing a portable AAS pharmacy behind their rides. I'm going to try and get there early to see Carl Lanore of Super Human Radio.

YOU'RE KILLING ME!

Are you going to see the Mr.O????

I have a link from bodybuilding.com to see it via the Internet...BUT...to see it live!!!!

Marco, take a ton of pics and post them here on the forum.

BTW, not everyone likes Carl...and I don't know why...but I do.

I listen to him a lot especially his interviews with Dr. Crisler.
 
YOU'RE KILLING ME!

Are you going to see the Mr.O????

I have a link from bodybuilding.com to see it via the Internet...BUT...to see it live!!!!

Marco, take a ton of pics and post them here on the forum.

BTW, not everyone likes Carl...and I don't know why...but I do.

I listen to him a lot especially his interviews with Dr. Crisler.

Won't be at the show, only the expo. Dr. John will be in town in a couple days also. Too bad I can't get into that seminar.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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