Do Low Testosterone Levels Cause Prostate Cancer? Harvard Urologist Explains

madman

Super Moderator

In this episode, Dr. Morgentaler talks about how low testosterone—not high—might actually be the real risk factor for prostate cancer, challenging decades of outdated beliefs.


00:28 – Historical Beliefs and Misconceptions

For decades, doctors thought testosterone fueled prostate cancer like gas on a fire—but that fear was based on outdated science.


03:27 – The Traverse Trial: Debunking Myths

A massive 2023 study proved testosterone therapy doesn’t raise prostate cancer risk—finally putting that old myth to rest.


06:00 – Exploring Low Testosterone as a Risk Factor

Now the big question is: could low testosterone actually make prostate cancer more likely?


06:56 – Gleason Scores and Testosterone Levels

Turns out, the more aggressive the cancer, the lower the testosterone levels tend to be.


11:25 – Animal Studies and Final Thoughts

Even lab studies in rats and cancer cells suggest low testosterone may feed tumor growth—flipping the old story on its head.
 
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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