Do changes in body weight affect dose response?

Hi - interesting post
Also treading very similar path, started 100mg Test cyp & HCG with clinic , bloods come back way over etc...
left as tbey wanted to just leave me on same doseage and felt that what was point in paying £150 a month to not even be getting Drs consultation/advice so started going alone with a reputable UGL.
Tried various esthers /doseages/HCG/proviron/pregnalone/DHEA etc
Found I responded positively to Sustanon better than Cyp & Prop
Reduced down to 90mg/wk Sustanon (bloods just over top end)

Currently @ 75mg 3 x week Sun pm/ Wed am/Fri noon
and HCG 300iu Tue am /Thurs noon/Sat pm
doing a 12 week stint before bloods in new year

Going to continue Dialing in around 50/60/75mg and similarly with HCG to keep balls functioning as i tried without for a month, and my libido/balls ground to a halt.

After a TBi and major accident my libido is shot compared to old me but i have improved EF symptons and Ejaculation frequency to a consistent 2 or 3 a week (as opposed to daily) pre crash but it was 1 every 2 weeks Pre TRT.

If you want any recomendation UGL wise PM me got a great UK lab with consistent results tests wise.

Keep us informed how you go please & good luck sir

I'm curious what lab you're using - i'm using Southern Ghost, very popular at the moment in the UK
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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