Diet lacking vitamin K1 makes knee joint susceptible to arthritis

[Nelson Vergel]

"There is a plausible rationale for the association of vitamin K with osteoarthritis", the researchers wrote. "Vitamin K acts as an essential co-factor for the process of gammacarboxylation of Gla proteins, thereby conferring functionality to vitamin K-dependent Gla proteins. The bone and cartilage Gla proteins, such as MGP, osteocalcin, and Gas-6, play an important role in regulation of mineralization in these tissues, and the absence of functional forms of these proteins results in changes that are similar to those that occur in osteoarthritis."

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