Dialing in my TRT, next steps

I've been running TRT for a while but am finally dialing in my TRT. Before and during TRT, my libido and EQ have been so-so. I have been taking 2.5mg of tadalafil daily, which sometimes does not work. I am thinking about raising it to 100mg every four days (175mg a week). These labs are based on 100mg every five days (140mg a week). No HCG. From what I read on Excelmale, my estrogen and free testosterone could be higher, ideally a T:E ratio around 10-20, and FT around 155 pg/mL.

So, I assume the strategy here is to increase my dose every six weeks and see if that gets me where I should be.
Total Test, MS, ng/dL: 806
Free Test, ED, pg/mL: 137.4
Estradiol, LC/MS, pg/mL: 26
SHBG, nmol/L: 29
DHT, LC/MS, ng/dL 38
Prolactin, ng/mL: 5.5
T:E Ratio: 31
T:E Ratio Percentage: 0.03225806452
 
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I've been running TRT for a while but am finally dialing in my TRT. Before and during TRT, my libido and EQ have been so-so. I have been taking 2.5mg of tadalafil daily, which sometimes does not work. I am thinking about raising it to 100mg every four days (175mg a week). These labs are based on 100mg every five days (140mg a week). No HCG. From what I read on Excelmale, my estrogen and free testosterone could be higher, ideally a T:E ratio around 10-20, and FT around 155 pg/mL.

So, I assume the strategy here is to increase my dose every six weeks and see if that gets me where I should be.
Total Test, MS, ng/dL: 806
Free Test, ED, pg/mL: 137.4
Estradiol, LC/MS, pg/mL: 26
SHBG, nmol/L: 29
DHT, LC/MS, ng/dL 38
Prolactin, ng/mL: 5.5
T:E Ratio: 31
T:E Ratio Percentage: 0.03225806452
I might try hCG here before raising the TRT dose. It can be helpful in cases like yours with a high T/E2 ratio, some headroom for additional E2, and lackluster libido / sexual function.
 
I might try hCG here before raising the TRT dose. It can be helpful in cases like yours with a high T/E2 ratio, some headroom for additional E2, and lackluster libido / sexual function.
That's the thing. I did a protocol for six weeks this summer of 70mg a week, a shot every 3.5 days, and 1000iu a week EOD.
Total Test, MS, ng/dL: 785
Free Test, ED, pg/mL: 138.3
Estradiol, LC/MS, pg/mL: 32
SHBG, nmol/L: 32
DHT, LC/MS, ng/dL: 41
Prolactin, ng/mL: 5.9
T:E Ratio: 24.53125
T:E Ratio Percentage: 0.04076433121
Still, so so on the results of EQ and libido, but full testes.
 
That's the thing. I did a protocol for six weeks this summer of 70mg a week, a shot every 3.5 days, and 1000iu a week EOD.
Total Test, MS, ng/dL: 785
Free Test, ED, pg/mL: 138.3
Estradiol, LC/MS, pg/mL: 32
SHBG, nmol/L: 32
DHT, LC/MS, ng/dL: 41
Prolactin, ng/mL: 5.9
T:E Ratio: 24.53125
T:E Ratio Percentage: 0.04076433121
Still, so so on the results of EQ and libido, but full testes.
Ok, if that didn't work, I would see what happens with raising the dose. Your DHT is pretty low too I'm noticing. If you don't get anywhere with the increased dose, some other things you might try: scrotal cream, prop, and adding DHEA.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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