Dialing in estradiol

Jim, do you, or did you ever use HCG alongside this? If so, how often do you dose it? Do you know where your ultrasensitive E2 levels generally are? Thanks brother

Yes...I take a small dose of HCG 3 times a week and do frequent labs. My E2 levels are very slightly on the high side and I feel better that way. I'm a fast metabolizer
 
Yes...I take a small dose of HCG 3 times a week and do frequent labs. My E2 levels are very slightly on the high side and I feel better that way. I'm a fast metabolizer

That's good to hear. So ok, you do 2 test shots per week, and 3 HCG. What's your HCG dose? If you don't mind me asking, do you know if you've maintained your fertility on this regimen? Thank you very much
 
That's good to hear. So ok, you do 2 test shots per week, and 3 HCG. What's your HCG dose? If you don't mind me asking, do you know if you've maintained your fertility on this regimen? Thank you very much

Yes..I follow Nelson's protocol of shallow intramuscular in the shoulder and 250 HCG 3 times a week. I don't care about fertility. I'm 49 and have 2 great grown kids.
 
Quick update. I've been on .5 mg arimidex 2x per week for 2 weeks now. Feeling pretty good, though I am getting ridiculously hot again at night (this happened when my e2 got out of control last time). I'll let the labs speak for themselves in a couple of weeks. Looking like I will be moving to EOD injections pretty soon.
 
UPDATE 1/29

Much to my surprise, and excitement, after running EOD injections for both testosterone and HCG, and reducing to .25mg adex EOD, my labs are as follows:

TT 1234
FT 34.2
E2 (sensitive) 17 ref(8-35)

I'm a little torn at this point, whether to attempt to discontinue arimidex completely, or to taper a bit more. excited to see how I feel when I get that T:E2 ratio down a little more.
 
If you are getting your AI from a compounding pharmacy, you can easily get doses less that 0.25mg. You may be fine with no AI though on your current protocol.
 
Not currently, as I was on an unfortunately whopping dose.

In your experience, does it cost significantly more to fill through a compounding pharmacy? Do you know if there is anything they could do with my current supply of 1mg pills? Now that I've cut the dose by 75%, I have 3 months worth or so.
 
Cut them. I chop my 1mg pills into quarters with a big chefs knife. Never a problem.

Chopping them only works well to cut them in half (0.5mg) or quarters (0.25mg), which is why I mentioned compounding labs for dosing less than 0.25mg. I suppose if you took a razor blade you *might* be able to cut the quarters in half again, but it would be a challenge to not cut your self and to be sure they are evenly split.
 
I missed the specific dosing you are moving towards. Another option is to dissolve the pills in alcohol then use a dropper. This works well, provides a very high degree of precision, and is one way to use up your inventory.
 
Chopping them only works well to cut them in half (0.5mg) or quarters (0.25mg), which is why I mentioned compounding labs for dosing less than 0.25mg. I suppose if you took a razor blade you *might* be able to cut the quarters in half again, but it would be a challenge to not cut your self and to be sure they are evenly split.

You're correct. Even quarters is a challenge using a razor blade. My pill cutter can't even half the pills without obliterating them. I think I'll do .25 e3d and reassess in a few weeks.
 
UPDATE 1/29

Much to my surprise, and excitement, after running EOD injections for both testosterone and HCG, and reducing to .25mg adex EOD, my labs are as follows:

TT 1234
FT 34.2
E2 (sensitive) 17 ref(8-35)

I'm a little torn at this point, whether to attempt to discontinue arimidex completely, or to taper a bit more. excited to see how I feel when I get that T:E2 ratio down a little more.

If you referenced this earlier, please excuse the question, but are you still injecting 200mg of testosterone on a weekly basis? If not, how much are you taking?
 
UPDATE 1/29

Much to my surprise, and excitement, after running EOD injections for both testosterone and HCG, and reducing to .25mg adex EOD, my labs are as follows:

TT 1234
FT 34.2
E2 (sensitive) 17 ref(8-35)

I'm a little torn at this point, whether to attempt to discontinue arimidex completely, or to taper a bit more. excited to see how I feel when I get that T:E2 ratio down a little more.

Just curious as to what your doctors have to say about all of this? The very same doctors that were using the wrong E2 test to base their dosage (or should I say, overdosage) of Adex that you were taking before. Did you change your protocol on your own, and get their blessing, or are you just doing this all by yourself now?

Personally, I would stop the Adex, or at least go down to .15mg BIW (from a compounding pharmacy), as your sensitive E2 is still pretty low.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
5
Guests online
380
Total visitors
385

Latest posts

Back
Top