Dhea usage

I, like many anti aging Physicians, believe that Pregnenolone and DHEA supplementation is part of any good TRT protocol.

I have been taking 50 mg of each every morning for years.

Dr. John Crisler loves it because, as he puts it, "it back fills the pathways" when a man is on TRT.

Life Extension Foundation had written extensively on the health benefits of both so you may want to go to www.lef.org and do some research.

It's best to take the two in micronized slow release form of best uptake. www.dhea.com has both and in pharmacy grade to boot!
 
I take that brand but just 25 each morning I thought dr crisler said a few years back if slow released 25 was enough and that 50 was only needed if it was not slow released. I've been worried that taking more will raise my estradiol too high cause of it converting over to estrogen.
 
I take that brand but just 25 each morning I thought dr crisler said a few years back if slow released 25 was enough and that 50 was only needed if it was not slow released. I've been worried that taking more will raise my estradiol too high cause of it converting over to estrogen.

Hey, if 25 mg of a high quality product is working for you and you have no neg sides...keep it up!!!
 
I, like many anti aging Physicians, believe that Pregnenolone and DHEA supplementation is part of any good TRT protocol.

I have been taking 50 mg of each every morning for years.

Dr. John Crisler loves it because, as he puts it, "it back fills the pathways" when a man is on TRT.

Life Extension Foundation had written extensively on the health benefits of both so you may want to go to www.lef.org and do some research.

It's best to take the two in micronized slow release form of best uptake. www.dhea.com has both and in pharmacy grade to boot!


DHEA jacks up my E too much and pregnenelone jacks up my cortisol too much at 50 mg each. I think I need a lower dose
 
DHEA jacks up my E too much and pregnenelone jacks up my cortisol too much at 50 mg each. I think I need a lower dose

I get some of the same thing with DHEA, within 48hrs of cheap oral delivery, I feel super aggressive and irritable. I'm about to try the pharmacy grade version as I've tested low in DHEA-S in the past. I'm able to tolerate just 12.5mg of that cheap DHEA. I'm sure it spiked my E2
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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