madman
Super Moderator
View attachment 28470View attachment 28471View attachment 28472My previous post was accidentally deleted so here we go.
Im 50 185 lbs / fit, somewhat...
I had various labs done & my numbers arent tanked. The clinics make it sound like a cure-all / used care salesman....
Im dealing with irritability / moodiness, may be just my personality & has nothing to do with my levels...
Cant sleep to save my life, bed at 8, 9, 11 doesnt matter, im up at 1;30 am & cant go back to sleep afterwards..
memory & train of thought is in the toilet, may be age related...
ed / bedroom performance issues, wasnt what it was....
The first clinic I went to labs were dont about 11 am fasted. They did do a free direct test. But also did some sort of calculation to find what my bioavailable usable calculated free testosterone level was & state im a low normal at the 643 total T value along with the 15.2 free test value. They stated they feel I would really benefit from trt....
Since then my defy labs are the lowest.
Just trying to get some thoughts from guys that really understand this stuff as I dont,
I know I can fix some issues & bring-on other issues.
My numbers arent tanked & trying to make the right decision for the right reasons...
I did labs with a local clinic & then due to discussing things with madman & was made aware of Defy I opted to do some additional test & free test, igf1, etc labs & here we are!
The attachment is the recent blood work ordered from defy.
what does the high igf1 mean???
Once again sorry for starting over & would love some thoughts on the matter.
thx
most recent blood draw is bottom attachment
estradiol sens 28.1
igf1 353
test 503
free test 11.2
Hard to believe you tested TT/estradiol using the most accurate assays (LC/MS-MS) yet did a 360 on one of the most critical markers FT!
Go figure!
One of the highlights from a recent lecture
*Results from the American College of Pathologists Proficiency Testing Survey CAP Y-B, 2021
*Total number of 34 laboratories with 5 different platforms participated:
*1-4: 4 commercial IA manufacturers; 5: Mass spectrometry -based-assay
Proficiency Testing survey (2021)
Here is the graph showing the data from the recent CAP survey on one sample. There are 34 laboratory participants and they are grouped by the different assay platforms used. There are four different immunoassay platforms and the mass spec is grouped into one category.
So we demonstrated the results for the report from CAP the measured free testosterone concentration at medium, lowest, and highest levels, and the mean with 3 standard deviations if the peer group has sufficient participants.
So you can see very clearly that is kind of consistent with this finding there is a big difference between the mass spec generated levels versus immunoassay results.
Here we see up to a tenfold difference with the mass spec results much higher and within the immunoassay group which you can also see on the right side so also the obvious variability is observed among the groups and also within the group.
So for one survey even with this limitation with the sample commutabilities and also it is not an accuracy-based survey but this data still clearly indicate the high variability across methods.